HCSGD entry for SEMA4D
1. General information
| Official gene symbol | SEMA4D |
|---|---|
| Entrez ID | 10507 |
| Gene full name | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| Other gene symbols | C9orf164 CD100 M-sema-G SEMAJ coll-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA IMP | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | IMP | molecular_function |
| GO:0005102 | Receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008360 | Regulation of cell shape | IMP | biological_process |
| GO:0010693 | Negative regulation of alkaline phosphatase activity | IEA IMP | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IMP | biological_process |
| GO:0030215 | Semaphorin receptor binding | IEA ISS | molecular_function |
| GO:0030335 | Positive regulation of cell migration | IDA IEA ISS | biological_process |
| GO:0031344 | Regulation of cell projection organization | IMP | biological_process |
| GO:0032321 | Positive regulation of Rho GTPase activity | IEA IMP ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043931 | Ossification involved in bone maturation | IEA IMP | biological_process |
| GO:0045668 | Negative regulation of osteoblast differentiation | IEA ISS | biological_process |
| GO:0048672 | Positive regulation of collateral sprouting | IMP | biological_process |
| GO:0048814 | Regulation of dendrite morphogenesis | IMP | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IEA ISS | biological_process |
| GO:0050732 | Negative regulation of peptidyl-tyrosine phosphorylation | IEA ISS | biological_process |
| GO:0050772 | Positive regulation of axonogenesis | IEA | biological_process |
| GO:0070486 | Leukocyte aggregation | IMP | biological_process |
| GO:0071526 | Semaphorin-plexin signaling pathway | IMP | biological_process |
| GO:1900220 | Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9540981802 | 0.0926414650 | 0.9999902473 | 0.5798848989 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0042652135 |
| GSE13712_SHEAR | Down | -0.4277544795 |
| GSE13712_STATIC | Down | -0.3780176933 |
| GSE19018 | Down | -0.0736043192 |
| GSE19899_A1 | Down | -0.0959088438 |
| GSE19899_A2 | Down | -0.9415481867 |
| PubMed_21979375_A1 | Up | 0.0220425400 |
| PubMed_21979375_A2 | Down | -0.1492550329 |
| GSE35957 | Down | -0.0405100658 |
| GSE36640 | Down | -1.3361149152 |
| GSE54402 | Down | -0.4184628195 |
| GSE9593 | Up | 0.1251070963 |
| GSE43922 | Up | 0.0357459474 |
| GSE24585 | Down | -0.0975535126 |
| GSE37065 | Up | 0.0706886997 |
| GSE28863_A1 | Down | -0.0985680032 |
| GSE28863_A2 | Down | -0.1311629940 |
| GSE28863_A3 | Up | 0.3234008602 |
| GSE28863_A4 | Up | 0.1574327406 |
| GSE48662 | Down | -0.0214359599 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004149 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004149 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017224 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT024017 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024391 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-484 | MIMAT0002174 | MIRT042320 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050315 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
