HCSGD entry for CEBPA

1. General information

Official gene symbolCEBPA
Entrez ID1050
Gene full nameCCAAT/enhancer binding protein (C/EBP), alpha
Other gene symbolsC/EBP-alpha CEBP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000050Urea cycleIEAbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusNAScellular_component
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006351Transcription, DNA-templatedIDA NASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0019221Cytokine-mediated signaling pathwayNASbiological_process
GO:0030099Myeloid cell differentiationNASbiological_process
GO:0030225Macrophage differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033274Response to vitamin B2IEAbiological_process
GO:0035189Rb-E2F complexIEAcellular_component
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045600Positive regulation of fat cell differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0045945Positive regulation of transcription from RNA polymerase III promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0048839Inner ear developmentIEAbiological_process
GO:0050872White fat cell differentiationIEAbiological_process
GO:0050873Brown fat cell differentiationIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30829623870.22808070360.99999024730.9196250306

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0274249804
GSE13712_SHEARDown-0.2018303220
GSE13712_STATICDown-0.1517061478
GSE19018Up0.2202570914
GSE19899_A1Up0.1112265535
GSE19899_A2Up0.1064987244
PubMed_21979375_A1Up0.0261485124
PubMed_21979375_A2Up0.0846491785
GSE35957Down-0.0997755237
GSE36640Up0.0019829577
GSE54402Down-0.1873292761
GSE9593Down-3.0075910154
GSE43922Up0.0486975967
GSE24585Up0.8252836639
GSE37065Down-0.0357892099
GSE28863_A1Down-0.0745608323
GSE28863_A2Down-0.2570056267
GSE28863_A3Up0.4283686080
GSE28863_A4Up0.1586281618
GSE48662Down-0.1051836601

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT000390Luciferase reporter assayFunctional MTI18818206
hsa-miR-124-3pMIMAT0000422MIRT002025Luciferase reporter assay//Western blot//Reporter assayFunctional MTI18451139
hsa-miR-124-3pMIMAT0000422MIRT002025MicroarrayFunctional MTI (Weak)15685193
hsa-miR-138-5pMIMAT0000430MIRT005488qRT-PCRFunctional MTI (Weak)20486779
hsa-miR-1226-3pMIMAT0005577MIRT036497CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037622CLASHFunctional MTI (Weak)23622248
hsa-miR-193a-5pMIMAT0004614MIRT038606CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045932CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23657974Adipogenic hormone cocktail induced expression of the adipogenic key regulators peroxisome proliferator-activated receptor-gamma2 and CCAAT/enhancer-binding protein alpha was significantly reduced in senescent adipose-derived stromal/ progenitor cells
22391813Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha
22391813CCAAT/enhancer-binding protein alpha (CEBPA) which was important to regulate differentiation of hepatocytes was found as the direct target downregulated by YY1
22391813Restoration of CEBPA in YY1-expressing HCC cells induced cellular differentiation and growth inhibition while knockdown of CEBPA expression in non-tumor liver cells promoted cell growth
22391813In summary, our study demonstrated that YY1 could promote hepatocellular carcinogenesis and inhibit cellular differentiation through the downregulation of CEBPA expression
21627568The expression of peroxisome proliferator activator receptor gamma 2 (PPARgamma2) and CCAAT/enhancer binding protein alpha (C/EBPalpha) in TDSCs after adipogenic induction decreased with passaging
21188535Real time RT-PCR demonstrated that both C/EBPalpha and PPARgamma decreased in senescent BM-MSC
21188535However, in UC-MSC, PPARgamma decreased but C/EBPalpha increased in late phase compared to early phase
21188535C/EBPalpha and PPARgamma could regulate the balance of adipogenic differentiation in BM-MSC but only PPARgamma not C/EBPalpha was involved in the adipogenic differentiation in UC-MSC
19526322The mRNA levels of CCAAT/enhancer-binding protein (C/EBP)alpha, peroxisome proliferator-activated receptor (PPAR)gamma and S100A1 were maximal during adipocyte differentiation and then significantly decreased
19526322LPS decreased the mRNA levels of C/EBPalpha and PPARgamma at all time points, as well as those of GLUT4, IRS-1 and adiponectin
10092208Analysis of the expression of relevant hepatic genes by reverse Northern and semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that culturing hepatocytes in collagen gels results in a sustained higher expression of key liver transcription factor genes DBP, C/EBP-alpha and -beta, and HNF-1 and -4, as well as specific liver enzyme genes (phosphoenol pyryvate carboxykinase, and carbamoylphosphate-synthetase I)
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