HCSGD entry for TADA3
1. General information
| Official gene symbol | TADA3 |
|---|---|
| Entrez ID | 10474 |
| Gene full name | transcriptional adaptor 3 |
| Other gene symbols | ADA3 NGG1 STAF54 TADA3L hADA3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001932 | Regulation of protein phosphorylation | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IMP | biological_process |
| GO:0016922 | Ligand-dependent nuclear receptor binding | IPI | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IEA | molecular_function |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | TAS | biological_process |
| GO:0030914 | STAGA complex | IDA IEA | cellular_component |
| GO:0031063 | Regulation of histone deacetylation | IEA | biological_process |
| GO:0031647 | Regulation of protein stability | IEA | biological_process |
| GO:0033276 | Transcription factor TFTC complex | IDA | cellular_component |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0072686 | Mitotic spindle | IEA | cellular_component |
| GO:0090043 | Regulation of tubulin deacetylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9274414498 | 0.1108736484 | 0.9999902473 | 0.6377415428 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0049956583 |
| GSE13712_SHEAR | Up | 0.1133244980 |
| GSE13712_STATIC | Down | -0.0676495343 |
| GSE19018 | Up | 0.0331458058 |
| GSE19899_A1 | Down | -0.3406383194 |
| GSE19899_A2 | Down | -0.1624232323 |
| PubMed_21979375_A1 | Down | -0.4732486301 |
| PubMed_21979375_A2 | Up | 0.3830638761 |
| GSE35957 | Down | -0.3053061386 |
| GSE36640 | Down | -0.2877735880 |
| GSE54402 | Up | 0.0740154907 |
| GSE9593 | Down | -0.0934981487 |
| GSE43922 | Up | 0.0032608368 |
| GSE24585 | Up | 0.1436492223 |
| GSE37065 | Down | -0.1364859084 |
| GSE28863_A1 | Down | -0.0909974180 |
| GSE28863_A2 | Down | -0.3859053506 |
| GSE28863_A3 | Down | -0.3341896488 |
| GSE28863_A4 | Down | -0.1557664712 |
| GSE48662 | Down | -0.0217474835 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028985 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045064 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17452980 | Expression of the N-terminal domain of hAda3 that binds p53 but not p300 blocked p14ARF-induced p53 acetylation and protected MECs from senescence |
| 17452980 | Consistent with these findings, the human papillomavirus 16 E6 mutant Y54D, which selectively targets hAda3 but not p53 for degradation and protects MECs from p14ARF-induced senescence, inhibited p53 acetylation |
| 17452980 | In H1299 cells, hAda3 overexpression increased p300-mediated p53 acetylation, which conversely decreased following small interfering RNA (siRNA) knockdown of hAda3 |
| 17452980 | Moreover, depletion of hAda3 by siRNA inhibited endogenous p53 acetylation and accumulation of p21cip1 in response to ectopic p14ARF |
| 17452980 | These studies reveal that, in addition to its known ability to inhibit Mdm2-mediated p53 degradation, p14ARF signals through hAda3 to stimulate p53 acetylation and the induction of cell senescence |
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