HCSGD entry for MAD2L2

1. General information

Official gene symbolMAD2L2
Entrez ID10459
Gene full nameMAD2 mitotic arrest deficient-like 2 (yeast)
Other gene symbolsMAD2B POLZ2 REV7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001558Regulation of cell growthIGIbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005819SpindleIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIGIbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007015Actin filament organizationIMPbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0008432JUN kinase bindingIDAmolecular_function
GO:0010719Negative regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0010944Negative regulation of transcription by competitive promoter bindingIMPbiological_process
GO:0016035Zeta DNA polymerase complexIDAcellular_component
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0042177Negative regulation of protein catabolic processIDAbiological_process
GO:0042772DNA damage response, signal transduction resulting in transcriptionIDAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0060564Negative regulation of mitotic anaphase-promoting complex activityIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:2000048Negative regulation of cell-cell adhesion mediated by cadherinIMPbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94097076100.01212534480.99999024730.2174054496

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1566136609
GSE13712_SHEARDown-0.8969417573
GSE13712_STATICDown-0.5303729057
GSE19018Up0.1647840349
GSE19899_A1Down-0.6550921542
GSE19899_A2Down-1.0458374589
PubMed_21979375_A1Up1.2741270737
PubMed_21979375_A2Down-1.5692055630
GSE35957Down-1.1907213385
GSE36640Down-1.2058935834
GSE54402Down-0.0302695513
GSE9593Down-0.3004969801
GSE43922Up0.0211366601
GSE24585Down-0.0060759309
GSE37065Down-0.1333019289
GSE28863_A1Up0.0048817383
GSE28863_A2Up0.3766967345
GSE28863_A3Down-0.4383323594
GSE28863_A4Down-0.0015018890
GSE48662Up0.0451545010

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002570MicroarrayFunctional MTI (Weak)18668037
hsa-miR-124-3pMIMAT0000422MIRT002570MicroarrayFunctional MTI (Weak)15685193
hsa-miR-1229-3pMIMAT0005584MIRT036379CLASHFunctional MTI (Weak)23622248
hsa-miR-187-3pMIMAT0000262MIRT047029CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.