HCSGD entry for VAV3

1. General information

Official gene symbolVAV3
Entrez ID10451
Gene full namevav 3 guanine nucleotide exchange factor
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityEXP TASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005096GTPase activator activityTASmolecular_function
GO:0005154Epidermal growth factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006906Vesicle fusionIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030676Rac guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045785Positive regulation of cell adhesionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68829648950.53607358760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0464912181
GSE13712_SHEARUp0.0198907324
GSE13712_STATICUp0.1882148541
GSE19018Up0.0816947499
GSE19899_A1Up0.0424431095
GSE19899_A2Up0.0792315517
PubMed_21979375_A1Down-0.0577287837
PubMed_21979375_A2Up0.0011590209
GSE35957Up0.0529074757
GSE36640Up0.0447047545
GSE54402Up0.0173201842
GSE9593Up0.0256440279
GSE43922Up0.0109738489
GSE24585Down-0.6776949667
GSE37065Up0.6705802041
GSE28863_A1Down-0.0290877332
GSE28863_A2Down-0.0777074579
GSE28863_A3Up0.0893826788
GSE28863_A4Up0.0108400869
GSE48662Down-0.1376961858

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016326MicroarrayFunctional MTI (Weak)20304954
hsa-miR-186-5pMIMAT0000456MIRT021094SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027493MicroarrayFunctional MTI (Weak)19088304
hsa-miR-149-5pMIMAT0000450MIRT045501CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.