HCSGD entry for PRMT5
1. General information
| Official gene symbol | PRMT5 |
|---|---|
| Entrez ID | 10419 |
| Gene full name | protein arginine methyltransferase 5 |
| Other gene symbols | HRMT1L5 IBP72 JBP1 SKB1 SKB1Hs |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000387 | Spliceosomal snRNP assembly | IMP TAS | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006479 | Protein methylation | IEA | biological_process |
| GO:0007088 | Regulation of mitosis | TAS | biological_process |
| GO:0008168 | Methyltransferase activity | IDA IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008469 | Histone-arginine N-methyltransferase activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0018216 | Peptidyl-arginine methylation | IMP | biological_process |
| GO:0019918 | Peptidyl-arginine methylation, to symmetrical-dimethyl arginine | IMP | biological_process |
| GO:0034660 | NcRNA metabolic process | TAS | biological_process |
| GO:0034709 | Methylosome | IDA | cellular_component |
| GO:0035243 | Protein-arginine omega-N symmetric methyltransferase activity | IMP | molecular_function |
| GO:0035246 | Peptidyl-arginine N-methylation | IDA | biological_process |
| GO:0042118 | Endothelial cell activation | IMP | biological_process |
| GO:0043021 | Ribonucleoprotein complex binding | IPI | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043985 | Histone H4-R3 methylation | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0401016793 | 0.8740327723 | 0.4495030651 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4962077840 |
| GSE13712_SHEAR | Up | 0.2773535193 |
| GSE13712_STATIC | Up | 0.2462221769 |
| GSE19018 | Down | -0.2449619829 |
| GSE19899_A1 | Up | 0.6629463876 |
| GSE19899_A2 | Up | 0.5518936842 |
| PubMed_21979375_A1 | Up | 1.1473528988 |
| PubMed_21979375_A2 | Up | 0.6936869526 |
| GSE35957 | Down | -0.4943075300 |
| GSE36640 | Down | -0.2177310269 |
| GSE54402 | Up | 0.1441920904 |
| GSE9593 | Down | -0.2786022142 |
| GSE43922 | Up | 0.2466408626 |
| GSE24585 | Down | -0.1706102712 |
| GSE37065 | Up | 0.0447633345 |
| GSE28863_A1 | Down | -0.0294343130 |
| GSE28863_A2 | Up | 0.2284231335 |
| GSE28863_A3 | Down | -0.4841731074 |
| GSE28863_A4 | Up | 0.2772863496 |
| GSE48662 | Down | -0.0705938020 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT000982 | Western blot | Functional MTI | 18694959 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT000983 | Western blot | Functional MTI | 18694959 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT004350 | Western blot | Functional MTI | 18694959 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT004351 | Western blot | Functional MTI | 18694959 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT004352 | Western blot | Functional MTI | 18694959 |
| hsa-miR-346 | MIMAT0000773 | MIRT042720 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044499 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18676353 | When the expression of protein arginine methyltransferases (PRMTs), namely PRMT1, PRMT4, PRMT5 and PRMT6 was examined, a significant reduction was found in replicatively senescent cells as well as their catalytic activities against histone mixtures compared with the young cells |
| 18676353 | In contrast, both up- and down-regulations of symmetrically arginine-methylated proteins (the product of type II PRMTs including PRMT5) during replicative senescence were found |
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