HCSGD entry for YAP1
1. General information
| Official gene symbol | YAP1 |
|---|---|
| Entrez ID | 10413 |
| Gene full name | Yes-associated protein 1 |
| Other gene symbols | YAP YAP2 YAP65 YKI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001076 | RNA polymerase II transcription factor binding transcription factor activity | IEA | molecular_function |
| GO:0001570 | Vasculogenesis | IEA | biological_process |
| GO:0003143 | Embryonic heart tube morphogenesis | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008283 | Cell proliferation | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010837 | Regulation of keratinocyte proliferation | IEA | biological_process |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0030857 | Negative regulation of epithelial cell differentiation | IEA | biological_process |
| GO:0030903 | Notochord development | IEA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0035329 | Hippo signaling | TAS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046622 | Positive regulation of organ growth | IEA | biological_process |
| GO:0048339 | Paraxial mesoderm development | IEA | biological_process |
| GO:0048368 | Lateral mesoderm development | IEA | biological_process |
| GO:0060242 | Contact inhibition | IDA | biological_process |
| GO:0070064 | Proline-rich region binding | IEA | molecular_function |
| GO:0071480 | Cellular response to gamma radiation | IDA | biological_process |
| GO:0072091 | Regulation of stem cell proliferation | IEA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IEA | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7269881691 | 0.0357172410 | 0.9999902473 | 0.3572032675 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3463158286 |
| GSE13712_SHEAR | Down | -3.5697372008 |
| GSE13712_STATIC | Down | -1.4588370146 |
| GSE19018 | Down | -0.4064720464 |
| GSE19899_A1 | Up | 0.2913915830 |
| GSE19899_A2 | Down | -0.1601112535 |
| PubMed_21979375_A1 | Up | 0.2889949988 |
| PubMed_21979375_A2 | Up | 0.1068106105 |
| GSE35957 | Up | 0.0050788582 |
| GSE36640 | Down | -0.0902627795 |
| GSE54402 | Up | 0.0686078576 |
| GSE9593 | Up | 0.1216780615 |
| GSE43922 | Down | -0.0431788883 |
| GSE24585 | Down | -0.1394010165 |
| GSE37065 | Up | 0.0013072577 |
| GSE28863_A1 | Up | 0.1301829160 |
| GSE28863_A2 | Down | -0.0462957015 |
| GSE28863_A3 | Down | -0.5119747583 |
| GSE28863_A4 | Up | 0.0381900345 |
| GSE48662 | Up | 0.9840043295 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT006154 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT005047 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-630 | MIMAT0003299 | MIRT005580 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21274007 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT007299 | Western blot | Functional MTI | 23340296 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030244 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | NA | hsa-miR-375 | 20100814 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
