HCSGD entry for RAPGEF3

1. General information

Official gene symbolRAPGEF3
Entrez ID10411
Gene full nameRap guanine nucleotide exchange factor (GEF) 3
Other gene symbolsCAMP-GEFI EPAC EPAC1 HSU79275 bcm910
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005952CAMP-dependent protein kinase complexIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008603CAMP-dependent protein kinase regulator activityIEAmolecular_function
GO:0012505Endomembrane systemIEAcellular_component
GO:0016020MembraneTAScellular_component
GO:0017034Rap guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0019933CAMP-mediated signalingNASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030552CAMP bindingIEAmolecular_function
GO:0030822Positive regulation of cAMP catabolic processNASbiological_process
GO:0032486Rap protein signal transductionIMPbiological_process
GO:0032854Positive regulation of Rap GTPase activityIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0051496Positive regulation of stress fiber assemblyIMPbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31697740590.78977175640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0126843822
GSE13712_SHEARUp0.2006597639
GSE13712_STATICDown-0.1973089970
GSE19018Up0.0635010391
GSE19899_A1Up0.1158107305
GSE19899_A2Up0.1808331148
PubMed_21979375_A1Down-0.0841040634
PubMed_21979375_A2Up0.0690606043
GSE35957Up0.0941868523
GSE36640Up0.1623799820
GSE54402Up0.1456132937
GSE9593Up0.1669618377
GSE43922Up0.1125205392
GSE24585Down-0.2953528566
GSE37065Up0.0468508357
GSE28863_A1Down-0.1939207756
GSE28863_A2Down-0.0222191207
GSE28863_A3Up0.4027658543
GSE28863_A4Up0.1346619837
GSE48662Down-0.0472732547

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019181MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT023183MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24169561We previously reported that activation of a cAMP mediator, called Exchange protein directly activated by cAMP (EPAC) promotes cAMP analog- or ovarian steroid-induced decidualization in cultured human ESCs
23023872In this study, we tested the hypotheses that endothelial cells (ECs) derived from human umbilical cord blood (hCB-ECs) exhibit low permeability, which increases as hCB-ECs age and undergo senescence, and that the change in the permeability of hCB-ECs is due to changes in tight junction protein localization and the activity of exchange protein activated by cAMP (Epac)1
23023872The elevated permeability in late passage hCB-ECs was reduced by 25-40% by elevation of membrane-associated cAMP and activation of the Epac1 pathway
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