HCSGD entry for IFITM3
1. General information
| Official gene symbol | IFITM3 |
|---|---|
| Entrez ID | 10410 |
| Gene full name | interferon induced transmembrane protein 3 |
| Other gene symbols | 1-8U DSPA2b IP15 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0009607 | Response to biotic stimulus | IEA | biological_process |
| GO:0009615 | Response to virus | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031902 | Late endosome membrane | IEA | cellular_component |
| GO:0032897 | Negative regulation of viral transcription | IDA | biological_process |
| GO:0034341 | Response to interferon-gamma | IDA | biological_process |
| GO:0035455 | Response to interferon-alpha | IDA | biological_process |
| GO:0035456 | Response to interferon-beta | IDA | biological_process |
| GO:0045071 | Negative regulation of viral genome replication | IDA | biological_process |
| GO:0046597 | Negative regulation of viral entry into host cell | IDA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1352647088 | 0.0493253030 | 0.7434939362 | 0.4153203135 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0506860691 |
| GSE13712_SHEAR | Up | 0.2792558924 |
| GSE13712_STATIC | Up | 0.5099827222 |
| GSE19018 | Down | -0.5847234449 |
| GSE19899_A1 | Down | -0.8563752585 |
| GSE19899_A2 | Down | -0.8337391546 |
| PubMed_21979375_A1 | Down | -0.1466672956 |
| PubMed_21979375_A2 | Down | -0.3641585545 |
| GSE35957 | Down | -0.4729021607 |
| GSE36640 | Up | 1.0581282887 |
| GSE54402 | Down | -1.5234881133 |
| GSE9593 | Down | -0.0383684826 |
| GSE43922 | Down | -0.4534014917 |
| GSE24585 | Up | 1.1881680952 |
| GSE37065 | Up | 0.1972978779 |
| GSE28863_A1 | Up | 0.1341140588 |
| GSE28863_A2 | Up | 0.0417890961 |
| GSE28863_A3 | Up | 0.2746638897 |
| GSE28863_A4 | Up | 0.1806794691 |
| GSE48662 | Up | 0.1862335193 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | MIRT021237 | Microarray | Functional MTI (Weak) | 18057241 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029884 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
