HCSGD entry for CPQ
1. General information
| Official gene symbol | CPQ |
|---|---|
| Entrez ID | 10404 |
| Gene full name | carboxypeptidase Q |
| Other gene symbols | LDP PGCP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004180 | Carboxypeptidase activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005764 | Lysosome | IEA ISS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA ISS | cellular_component |
| GO:0005794 | Golgi apparatus | IEA ISS | cellular_component |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0006590 | Thyroid hormone generation | IEA ISS | biological_process |
| GO:0042246 | Tissue regeneration | IEA ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043171 | Peptide catabolic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070573 | Metallodipeptidase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2276413586 | 0.0278556096 | 0.9096323364 | 0.3175419299 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4589958989 |
| GSE13712_SHEAR | Down | -1.7626350441 |
| GSE13712_STATIC | Down | -1.2861645006 |
| GSE19018 | Up | 0.4230012883 |
| GSE19899_A1 | Down | -0.0083916005 |
| GSE19899_A2 | Up | 0.0174071183 |
| PubMed_21979375_A1 | Down | -0.7958625390 |
| PubMed_21979375_A2 | Up | 0.0586721773 |
| GSE35957 | Down | -0.1312717646 |
| GSE36640 | Up | 2.0519993049 |
| GSE54402 | Down | -1.3710630760 |
| GSE9593 | Up | 0.8173488027 |
| GSE43922 | Down | -0.0887302154 |
| GSE24585 | Up | 0.1920926205 |
| GSE37065 | Up | 0.0902599020 |
| GSE28863_A1 | Up | 0.2103743915 |
| GSE28863_A2 | Up | 0.5795651141 |
| GSE28863_A3 | Down | -0.1518344259 |
| GSE28863_A4 | Down | -0.2017144385 |
| GSE48662 | Down | -0.1025951675 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7020767 | 110, 421-430) decline exponentially throughout the erythrocyte life-span, with the exception of dipeptidyl aminopeptidase III |
| 7020767 | The calculated half-lives were: 60 days for the neutral endopeptidase; 87 days for the total acidic endopeptidase activity which is accounted for by three distinct enzymes; 49 days for aminopeptidase B and 133 days for a second aminopeptidase with broad substrate specificity; 84 days for dipeptidyl aminopeptidase II |
| 7020767 | The results obtained with the rabbit erythrocytes were: (a) no significant decline of leucine aminopeptidase, dipeptidyl aminopeptidase II and III activities in the transition from reticulocytes to mature erythrocytes; (b) very limited decline of aminopeptidase B activity; (c) a pronounced age-dependent decay, in increasing order, of neutral endopeptidase, aminopeptidase A, carboxypeptidase and acidic endopeptidase activities |
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