HCSGD entry for PIAS3
1. General information
| Official gene symbol | PIAS3 |
|---|---|
| Entrez ID | 10401 |
| Gene full name | protein inhibitor of activated STAT, 3 |
| Other gene symbols | ZMIZ5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA IPI | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009725 | Response to hormone | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0015459 | Potassium channel regulator activity | IEA | molecular_function |
| GO:0016925 | Protein sumoylation | IEA ISS | biological_process |
| GO:0019789 | SUMO ligase activity | IEA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0033235 | Positive regulation of protein sumoylation | IDA | biological_process |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0045838 | Positive regulation of membrane potential | IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6855654078 | 0.3549956575 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1199805893 |
| GSE13712_SHEAR | Down | -0.2782872954 |
| GSE13712_STATIC | Down | -0.0709648521 |
| GSE19018 | Up | 0.1320572761 |
| GSE19899_A1 | Down | -0.3660461480 |
| GSE19899_A2 | Down | -0.2234220559 |
| PubMed_21979375_A1 | Down | -0.2100664409 |
| PubMed_21979375_A2 | Up | 0.4842039467 |
| GSE35957 | Down | -0.1233194744 |
| GSE36640 | Up | 0.2830810652 |
| GSE54402 | Up | 0.2618384899 |
| GSE9593 | Down | -0.2099329457 |
| GSE43922 | Up | 0.0059978343 |
| GSE24585 | Up | 0.1838375306 |
| GSE37065 | Down | -0.0171025420 |
| GSE28863_A1 | Up | 0.0915962253 |
| GSE28863_A2 | Up | 0.2792007611 |
| GSE28863_A3 | Down | -0.2233693577 |
| GSE28863_A4 | Down | -0.2142867911 |
| GSE48662 | Down | -0.0997980467 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT006288 | Luciferase reporter assay | Functional MTI | 22316494 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047704 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
