HCSGD entry for NDRG1
1. General information
| Official gene symbol | NDRG1 |
|---|---|
| Entrez ID | 10397 |
| Gene full name | N-myc downstream regulated 1 |
| Other gene symbols | CAP43 CMT4D DRG-1 DRG1 GC4 HMSNL NDR1 NMSL PROXY1 RIT42 RTP TARG1 TDD5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005913 | Cell-cell adherens junction | IDA | cellular_component |
| GO:0008017 | Microtubule binding | IDA | molecular_function |
| GO:0010038 | Response to metal ion | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0017137 | Rab GTPase binding | IDA | molecular_function |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | IEP | biological_process |
| GO:0032287 | Peripheral nervous system myelin maintenance | IEA | biological_process |
| GO:0043015 | Gamma-tubulin binding | IDA | molecular_function |
| GO:0045296 | Cadherin binding | IDA | molecular_function |
| GO:0045576 | Mast cell activation | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0055038 | Recycling endosome membrane | IDA | cellular_component |
| GO:0071456 | Cellular response to hypoxia | IEP | biological_process |
| GO:0090232 | Positive regulation of spindle checkpoint | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0078379393 | 0.2758558755 | 0.2290469478 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2935468673 |
| GSE13712_SHEAR | Down | -0.3616982341 |
| GSE13712_STATIC | Up | 0.0727783806 |
| GSE19018 | Up | 3.3061357360 |
| GSE19899_A1 | Down | -0.2373529690 |
| GSE19899_A2 | Up | 0.9403817319 |
| PubMed_21979375_A1 | Up | 1.1238916405 |
| PubMed_21979375_A2 | Up | 1.4013600779 |
| GSE35957 | Down | -0.3347998155 |
| GSE36640 | Down | -1.4649450523 |
| GSE54402 | Up | 0.0718350061 |
| GSE9593 | Up | 0.0139070205 |
| GSE43922 | Up | 0.4030360450 |
| GSE24585 | Down | -0.4600354999 |
| GSE37065 | Up | 0.1890749162 |
| GSE28863_A1 | Up | 0.1465522982 |
| GSE28863_A2 | Up | 0.7690904544 |
| GSE28863_A3 | Down | -0.2440943848 |
| GSE28863_A4 | Down | -0.1633813617 |
| GSE48662 | Up | 0.4872102853 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018414 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025409 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038043 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041050 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052351 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24302615 | In this study, we further used a loss-of-function approach (RNA interference) to understand the role of NDRG1 in hepatocarcinogenesis |
| 24302615 | We found that suppression of NDRG1 significantly impaired HCC cell growth through inducing extensive cellular senescence of HCC cells both in vitro and in vivo, accompanied by cell cycle arrest at the G1 phase |
| 24302615 | The observed antitumor effects of NDRG1 suppression were correlated with activation of major senescence-associated signaling pathways, such as upregulation of tumor suppressors p53, p21 and p16, and decreased phosphorylated Rb |
| 24302615 | We found that high NDRG1 expression (n = 66) is associated with low p21 (n = 82; P < 0 |
| 20348948 | T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells |
| 20348948 | Using microarray analysis we identified a large cohort of novel TBX2-repressed target genes including the breast tumour suppressor NDRG1 (N-myc downregulated gene 1) |
| 20348948 | We show EGR1 is required for the ability of TBX2 to repress NDRG1 and drive cell proliferation |
| 20348948 | We show that TBX2 interacts with EGR1 and that TBX2 requires EGR1 to target the NDRG1 proximal promoter |
| 20348948 | NDRG1 can recapitulate these effects when transfected into TBX2-expressing cells |
| 20348948 | Together, these data identify a novel mechanism for TBX2-driven oncogenesis and highlight the importance of NDRG1 as a growth control gene in breast tissue |
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