HCSGD entry for DLC1

1. General information

Official gene symbolDLC1
Entrez ID10395
Gene full namedeleted in liver cancer 1
Other gene symbolsARHGAP7 HP STARD12 p122-RhoGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001843Neural tube closureISSbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0005100Rho GTPase activator activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005901CaveolaIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006915Apoptotic processIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008285Negative regulation of cell proliferationIDA IMPbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0008360Regulation of cell shapeIMPbiological_process
GO:0021575Hindbrain morphogenesisISSbiological_process
GO:0030036Actin cytoskeleton organizationISSbiological_process
GO:0030336Negative regulation of cell migrationIDA IMPbiological_process
GO:0030675Rac GTPase activator activityIDAmolecular_function
GO:0030900Forebrain developmentISSbiological_process
GO:0032320Positive regulation of Ras GTPase activityIDA IMPbiological_process
GO:0032321Positive regulation of Rho GTPase activityIDA IMPbiological_process
GO:0032956Regulation of actin cytoskeleton organizationIMPbiological_process
GO:0035024Negative regulation of Rho protein signal transductionIMPbiological_process
GO:0035307Positive regulation of protein dephosphorylationIDAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0043547Positive regulation of GTPase activityIDA IMPbiological_process
GO:0048041Focal adhesion assemblyISSbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051497Negative regulation of stress fiber assemblyIDAbiological_process
GO:1900119Positive regulation of execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87230787580.03958413430.99999024730.3749168766

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7660989570
GSE13712_SHEARUp0.1529641531
GSE13712_STATICUp0.1273168303
GSE19018Down-0.5296305622
GSE19899_A1Down-0.2753134924
GSE19899_A2Down-0.2664401311
PubMed_21979375_A1Down-0.3543733774
PubMed_21979375_A2Down-0.1781267108
GSE35957Down-0.2678257824
GSE36640Up0.2559514905
GSE54402Down-0.6820685441
GSE9593Up0.0875193853
GSE43922Down-0.4082395581
GSE24585Down-0.1242728594
GSE37065Down-0.0705690240
GSE28863_A1Up0.6161686221
GSE28863_A2Down-0.0254439507
GSE28863_A3Down-0.1403308843
GSE28863_A4Up0.2384936600
GSE48662Up0.0180083485

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT005042MicroarrayFunctional MTI (Weak)17699775
hsa-miR-186-5pMIMAT0000456MIRT021186SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031720SequencingFunctional MTI (Weak)20371350
hsa-let-7d-5pMIMAT0000065MIRT032148SequencingFunctional MTI (Weak)20371350
hsa-miR-877-3pMIMAT0004950MIRT036947CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT048014CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050541CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.