HCSGD entry for TUBB3
1. General information
| Official gene symbol | TUBB3 |
|---|---|
| Entrez ID | 10381 |
| Gene full name | tubulin, beta 3 class III |
| Other gene symbols | CDCBM CFEOM3A TUBB4 beta-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005874 | Microtubule | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0007017 | Microtubule-based process | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007411 | Axon guidance | IEA IMP | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0042277 | Peptide binding | IEA | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0051258 | Protein polymerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8937752517 | 0.1121604726 | 0.9999902473 | 0.6419168950 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0129166212 |
| GSE13712_SHEAR | Down | -0.1278066940 |
| GSE13712_STATIC | Up | 0.1307706513 |
| GSE19018 | Down | -0.2732789548 |
| GSE19899_A1 | Down | -0.1276127824 |
| GSE19899_A2 | Up | 0.1265288681 |
| PubMed_21979375_A1 | Up | 0.6862714980 |
| PubMed_21979375_A2 | Down | -0.3693010239 |
| GSE35957 | Down | -0.8928373842 |
| GSE36640 | Down | -0.5709661063 |
| GSE54402 | Up | 0.0480137150 |
| GSE9593 | Down | -0.4731391146 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0733138821 |
| GSE28863_A2 | Up | 0.1747957087 |
| GSE28863_A3 | Down | -0.1063779634 |
| GSE28863_A4 | Up | 0.0245893682 |
| GSE48662 | Down | -0.4955214662 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Epothilone D | DB01873 | EXPT01350 |
| Epothilone B | DB03010 | EXPT01349 |
| Ixabepilone | DB04845 | - |
| CYT997 | DB05147 | - |
| ZEN-012 | DB06042 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200c-3p | MIMAT0000617 | MIRT000196 | ELISA//Immunoblot//Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 19435871 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT000196 | Western blot | Functional MTI | 20049172 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016480 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016480 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019563 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028482 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031664 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041009 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049056 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
