HCSGD entry for TLR6

1. General information

Official gene symbolTLR6
Entrez ID10333
Gene full nametoll-like receptor 6
Other gene symbolsCD286
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA TASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030670Phagocytic vesicle membraneIEAcellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034150Toll-like receptor 6 signaling pathwayIEAbiological_process
GO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complexIEAcellular_component
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042088T-helper 1 type immune responseIC IEAbiological_process
GO:0042496Detection of diacyl bacterial lipopeptideIDA IEAbiological_process
GO:0042498Diacyl lipopeptide bindingIEAmolecular_function
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043507Positive regulation of JUN kinase activityIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045410Positive regulation of interleukin-6 biosynthetic processIEA ISSbiological_process
GO:0046209Nitric oxide metabolic processIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0071723Lipopeptide bindingISSmolecular_function
GO:0071726Cellular response to diacyl bacterial lipopeptideIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51757413850.41180043690.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0658085746
GSE13712_SHEARUp0.0056744435
GSE13712_STATICUp0.1275043725
GSE19018Down-0.0273980038
GSE19899_A1Down-0.0058210168
GSE19899_A2Down-0.1659593100
PubMed_21979375_A1Down-0.1490983006
PubMed_21979375_A2Down-0.0319846482
GSE35957Up0.0544396648
GSE36640Up0.1646385940
GSE54402Down-0.1045064301
GSE9593Up0.1681722311
GSE43922Down-0.4547670853
GSE24585Up1.0518207897
GSE37065Up0.0957301597
GSE28863_A1Up0.1313859039
GSE28863_A2Down-0.0706036875
GSE28863_A3Up0.0129655501
GSE28863_A4Down-0.1685454228
GSE48662Down-0.1948903168

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.