HCSGD entry for CDKN2D
1. General information
| Official gene symbol | CDKN2D |
|---|---|
| Entrez ID | 1032 |
| Gene full name | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| Other gene symbols | INK4D p19 p19-INK4D |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000731 | DNA synthesis involved in DNA repair | IMP | biological_process |
| GO:0004861 | Cyclin-dependent protein serine/threonine kinase inhibitor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009411 | Response to UV | IMP | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0032526 | Response to retinoic acid | IMP | biological_process |
| GO:0033280 | Response to vitamin D | IMP | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0048102 | Autophagic cell death | IMP | biological_process |
| GO:0071901 | Negative regulation of protein serine/threonine kinase activity | IDA | biological_process |
| GO:1902230 | Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4561720147 | 0.4748060066 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2726165615 |
| GSE13712_SHEAR | Down | -0.1416245425 |
| GSE13712_STATIC | Up | 0.1014785316 |
| GSE19018 | Up | 0.1452834531 |
| GSE19899_A1 | Down | -0.0838944137 |
| GSE19899_A2 | Down | -0.0680163368 |
| PubMed_21979375_A1 | Up | 0.3428326629 |
| PubMed_21979375_A2 | Down | -0.2902040603 |
| GSE35957 | Down | -0.3618263008 |
| GSE36640 | Up | 0.0029220786 |
| GSE54402 | Up | 0.0201607834 |
| GSE9593 | Up | 0.1304810485 |
| GSE43922 | Up | 0.0487738760 |
| GSE24585 | Up | 0.5110421669 |
| GSE37065 | Down | -0.0594035138 |
| GSE28863_A1 | Down | -0.1950642708 |
| GSE28863_A2 | Down | -0.1416711211 |
| GSE28863_A3 | Up | 0.1114908838 |
| GSE28863_A4 | Up | 0.2303670353 |
| GSE48662 | Up | 0.1616490601 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024530 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026171 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028887 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043416 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24667034 | The p19INK4d, a member of the family of cyclin-dependent kinase inhibitors (INK4), plays an important role on cell cycle regulation and in the cellular DNA damage response |
| 24667034 | We hypothesize that p19INK4d is a potential factor involved in the onset and/or maintenance of the senescent state |
| 24667034 | Changes in p19INK4d expression and localization during senescence were determined by Western blot and immunofluorescence assays |
| 24667034 | RESULTS: The data presented here show for the first time that p19INK4d expression is up-regulated by different types of senescence |
| 24667034 | Following a senescence stimulus, p19INK4d translocates to the nucleus and tightly associates with chromatin |
| 24667034 | Moreover, reduced levels of p19INK4d impair senescence-related global genomic heterochromatinization |
| 24667034 | Analysis of p19INK4d mRNA and protein levels in tissues from differently aged mice revealed an up-regulation of p19INK4d that correlates with age |
| 24667034 | CONCLUSION: We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction |
| 10851091 | Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle |
| 10851091 | Assembly and activity of the proto-oncogenic cyclin D/CDK4(6) complexes, the major driving force of G1 phase progression, is negatively regulated by a family of INK4 CDK inhibitors p16INK4a, p15INK4b, p18INK4c, and p19INK4d |
| 10851091 | Here we show that the periodic oscillation of the p19INK4d protein during the cell cycle is determined by the ubiquitin/proteasome-dependent mechanism, allowing the protein abundance to follow the changes in its mRNA expression |
| 10851091 | Within the INK4 family, this regulatory mode appears restricted to p19INK4d whose ubiquitination was dependent on the integrity of lysine 62, and binding to CDK4 |
| 10851091 | These results highlight unexpected differences among the INK4 inhibitors, and suggest how p19INK4d may help regulate the rate of cyclin D/CDK4(6) complex formation, and thereby timely progression through the mammalian cell division cycle |
| 9244355 | Both p18INK4c and p19INK4d were widely expressed during mouse embryogenesis, but p16INK4a and p15INK4b were not readily detected prenatally |
| 9244355 | Although p15INK4b, p18INK4c and p19INK4d were demonstrated in many tissues by 4 weeks after birth, p16INK4a protein expression was restricted to the lung and spleen of older mice, with increased, more widespread mRNA expression during aging |
| 9244355 | The levels of p16INK4a and p18INK4c, but not p15INK4b or p19INK4d, further increased as MEFs approached senescence |
| 9244355 | Whereas p18INK4c and p19INK4d may regulate pre- and postnatal development, p16INK4a more likely plays a checkpoint function during cell senescence that underscores its selective role as a tumor suppressor |
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