HCSGD entry for PAK4
1. General information
| Official gene symbol | PAK4 |
|---|---|
| Entrez ID | 10298 |
| Gene full name | p21 protein (Cdc42/Rac)-activated kinase 4 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | IBA | biological_process |
| GO:0004672 | Protein kinase activity | IEA NAS | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007010 | Cytoskeleton organization | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016049 | Cell growth | TAS | biological_process |
| GO:0016477 | Cell migration | TAS | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1982458721 | 0.7899682687 | 0.8604134520 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0668849429 |
| GSE13712_SHEAR | Down | -0.2213230562 |
| GSE13712_STATIC | Down | -0.1614730730 |
| GSE19018 | Up | 0.0806135783 |
| GSE19899_A1 | Up | 0.0278156250 |
| GSE19899_A2 | Up | 0.4403821236 |
| PubMed_21979375_A1 | Up | 0.8990991402 |
| PubMed_21979375_A2 | Up | 0.8355287878 |
| GSE35957 | Down | -0.3819832176 |
| GSE36640 | Down | -0.2400277848 |
| GSE54402 | Up | 0.1657777281 |
| GSE9593 | Down | -0.2909589104 |
| GSE43922 | Up | 0.1146032267 |
| GSE24585 | Up | 0.1559046822 |
| GSE37065 | Down | -0.0755390176 |
| GSE28863_A1 | Down | -0.1663882143 |
| GSE28863_A2 | Down | -0.0357852311 |
| GSE28863_A3 | Up | 0.2656504187 |
| GSE28863_A4 | Up | 0.1829214509 |
| GSE48662 | Up | 0.4209269682 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT006899 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22766504 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030445 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030445 | Luciferase reporter assay | Functional MTI | 23071155 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036391 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037459 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040764 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043240 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051766 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26297735 | Glioblastomas require integrin alphavbeta3/PAK4 signaling to escape senescence |
| 26297735 | Here, we demonstrate that integrin alphavbeta3 allows glioblastoma cells to counteract senescence through a novel tissue-specific effector mechanism involving recruitment and activation of the cytoskeletal regulatory kinase PAK4 |
| 26297735 | Mechanistically, targeting either alphavbeta3 or PAK4 led to emergence of a p21-dependent, p53-independent cell senescence phenotype |
| 26297735 | Moreover, alphavbeta3/PAK4 dependence was not found to be critical in epithelial cancers |
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