HCSGD entry for EFS
1. General information
| Official gene symbol | EFS |
|---|---|
| Entrez ID | 10278 |
| Gene full name | embryonal Fyn-associated substrate |
| Other gene symbols | CAS3 CASS3 EFS1 EFS2 HEFS SIN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9913523156 | 0.0035467269 | 0.9999902473 | 0.1210632124 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0328619186 |
| GSE13712_SHEAR | Up | 0.0455863049 |
| GSE13712_STATIC | Down | -0.2728331393 |
| GSE19018 | Down | -0.2326081004 |
| GSE19899_A1 | Down | -1.0432893377 |
| GSE19899_A2 | Down | -1.2203065662 |
| PubMed_21979375_A1 | Down | -3.0113550050 |
| PubMed_21979375_A2 | Down | -2.0556352555 |
| GSE35957 | Down | -0.8121731483 |
| GSE36640 | Down | -0.9578799208 |
| GSE54402 | Down | -0.3023510318 |
| GSE9593 | Down | -0.5563492022 |
| GSE43922 | Down | -0.5412618913 |
| GSE24585 | Up | 0.0288518820 |
| GSE37065 | Up | 0.1939459668 |
| GSE28863_A1 | Up | 0.1394089134 |
| GSE28863_A2 | Down | -0.1230809695 |
| GSE28863_A3 | Up | 0.0495076739 |
| GSE28863_A4 | Down | -0.0670247503 |
| GSE48662 | Down | -0.2976678854 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016538 | Microarray | Functional MTI (Weak) | 20304954 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26952515 | Univariate analysis (57 patients with available follow-up information) of survival (Kaplan Meier curves method) revealed a correlation between higher levels of TPX2, Ki-67 and hTERT markers and shorter event-free survival (EFS) or poorer overall survival (OS) |
| 26199387 | We hypothesized that CS mechanisms may have potential prognostic relevance in cHL and investigated whether the expression of the well-established CS biomarkers p21(CIP1/WAF1) and p16(INK4a) by HRS cells might be predictive of the probability of event-free survival (EFS) |
| 26199387 | A positive staining of one of the two molecules in more than 30% HRS cells predicted a better EFS (P < 0 |
| 25675863 | In BCR-ABL1+ ALLs, high CDK4 expression, phosphorylated pRb (p-pRb) and telomerase activity were significantly associated with a shorter disease-free survival (DFS) and event-free survival (EFS) |
| 22125259 | At sites of bone fracture, naturally-occurring electric fields (EFs) exist during healing and may guide cell migration |
| 22125259 | In this study, we investigated whether EFs could direct the migration of bone marrow mesenchymal stem cells (BM-MSCs), which are known to be key players in bone formation |
| 22125259 | Human BM-MSCs were cultured in direct current EFs of 10 to 600 mV/mm |
| 22125259 | Our findings indicate that EFs are a powerful cue in directing migration of human MSCs in vitro |
| 20364576 | OBJECTIVE: Epigenetic regulations of insulin-like growth factor 2 (IGF2) were observed during cellular replicative senescence and premature senescence induced by hydrogen peroxide of human embryonic lung fibroblasts (HEFs) |
| 19408652 | OBJECTIVE: To study both cellular replicative and prematuce senescence induced by hydrogen peroxide (H2O2) of human embryonic lung fibroblasts (HEFs) |
| 19408652 | METHODS: HEFs were cultured conventionally and treated with H2O2 |
| 19408652 | RESULTS: HEFs entered replicative senescence status at 52 population doubling levels (PDL) and 400 micromol/L H2O2 induced premature senescence of HEFs in a short period |
| 19196634 | We measured EFS-evoked [Ca(2+)](i) transients in isolated fura-2-loaded SCG cells from Fischer-344 rats aged 6, 12, and 24 months with either the RyR antagonist ryanodine to block the contribution of CICR to [Ca(2+)](i) transients or caffeine to sensitize CICR to EFS |
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