HCSGD entry for UBE4B
1. General information
| Official gene symbol | UBE4B |
|---|---|
| Entrez ID | 10277 |
| Gene full name | ubiquitination factor E4B |
| Other gene symbols | E4 HDNB1 UBOX3 UFD2 UFD2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IEA TAS | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008626 | Granzyme-mediated apoptotic signaling pathway | IDA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0019899 | Enzyme binding | ISS | molecular_function |
| GO:0034450 | Ubiquitin-ubiquitin ligase activity | IEA | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3154900460 | 0.1600005433 | 0.9999902473 | 0.7725874702 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1829436971 |
| GSE13712_SHEAR | Down | -0.4424667716 |
| GSE13712_STATIC | Down | -0.4169340318 |
| GSE19018 | Up | 0.3142391083 |
| GSE19899_A1 | Down | -0.2914935357 |
| GSE19899_A2 | Down | -0.2978631300 |
| PubMed_21979375_A1 | Down | -0.7822072326 |
| PubMed_21979375_A2 | Down | -0.0416420872 |
| GSE35957 | Up | 0.7535563104 |
| GSE36640 | Down | -0.1433507508 |
| GSE54402 | Up | 0.2326491153 |
| GSE9593 | Up | 0.4505426220 |
| GSE43922 | Down | -0.0540028981 |
| GSE24585 | Up | 0.3724803761 |
| GSE37065 | Down | -0.2205358273 |
| GSE28863_A1 | Up | 0.6095763006 |
| GSE28863_A2 | Up | 0.3461982704 |
| GSE28863_A3 | Down | -0.4262319374 |
| GSE28863_A4 | Down | -0.3597231546 |
| GSE48662 | Up | 0.3017070587 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016837 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042528 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049579 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
