HCSGD entry for DENND4A
1. General information
| Official gene symbol | DENND4A |
|---|---|
| Entrez ID | 10260 |
| Gene full name | DENN/MADD domain containing 4A |
| Other gene symbols | IRLB MYCPBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0032313 | Regulation of Rab GTPase activity | IDA | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | IDA | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0107862239 | 0.9925178565 | 0.2631178869 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0703798803 |
| GSE13712_SHEAR | Up | 0.9422581873 |
| GSE13712_STATIC | Up | 0.1551032968 |
| GSE19018 | Up | 0.6073912828 |
| GSE19899_A1 | Down | -0.1095416912 |
| GSE19899_A2 | Up | 0.4453450382 |
| PubMed_21979375_A1 | Up | 1.2038678797 |
| PubMed_21979375_A2 | Up | 0.6573606674 |
| GSE35957 | Up | 0.3902984527 |
| GSE36640 | Up | 1.1223174118 |
| GSE54402 | Up | 0.1962029967 |
| GSE9593 | Up | 0.4575671851 |
| GSE43922 | Down | -0.0424717396 |
| GSE24585 | Up | 0.1965374625 |
| GSE37065 | Up | 0.0232691475 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0310369260 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040677 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050274 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11846374 | Moreover, quiescence and senescence can be distinguished by increased expression of Irlb, c-Myc transcription factor, and Miz-1, c-Myc-interacting Zn finger protein 1, only in the former state |
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