HCSGD entry for ABCC4
1. General information
| Official gene symbol | ABCC4 |
|---|---|
| Entrez ID | 10257 |
| Gene full name | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
| Other gene symbols | EST170205 MOAT-B MOATB MRP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0010243 | Response to organonitrogen compound | IEA | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | NAS | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031088 | Platelet dense granule membrane | IDA TAS | cellular_component |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | IEA | molecular_function |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1685746590 | 0.1382442498 | 0.8090845060 | 0.7160029319 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0458556117 |
| GSE13712_SHEAR | Down | -0.0624820161 |
| GSE13712_STATIC | Up | 0.3428778899 |
| GSE19018 | Down | -0.6105225007 |
| GSE19899_A1 | Up | 0.0241392277 |
| GSE19899_A2 | Up | 0.2919399952 |
| PubMed_21979375_A1 | Down | -0.5751183882 |
| PubMed_21979375_A2 | Up | 1.0588252064 |
| GSE35957 | Up | 0.6702436852 |
| GSE36640 | Up | 1.1723936114 |
| GSE54402 | Down | -0.7104882376 |
| GSE9593 | Down | -0.0757747477 |
| GSE43922 | Up | 0.0870111777 |
| GSE24585 | Down | -0.8123285074 |
| GSE37065 | Down | -0.0648827702 |
| GSE28863_A1 | Up | 0.1054869940 |
| GSE28863_A2 | Up | 0.0072225505 |
| GSE28863_A3 | Down | -0.2723270706 |
| GSE28863_A4 | Up | 0.0487249855 |
| GSE48662 | Down | -0.2161811730 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004989 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020794 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023897 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031811 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043124 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046379 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
