HCSGD entry for SPRY2

1. General information

Official gene symbolSPRY2
Entrez ID10253
Gene full namesprouty homolog 2 (Drosophila)
Other gene symbolshSPRY2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010628Positive regulation of gene expressionIMPbiological_process
GO:0010801Negative regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030291Protein serine/threonine kinase inhibitor activityICmolecular_function
GO:0032587Ruffle membraneIEAcellular_component
GO:0033138Positive regulation of peptidyl-serine phosphorylationIMPbiological_process
GO:0034261Negative regulation of Ras GTPase activityIEAbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043085Positive regulation of catalytic activityIMPbiological_process
GO:0043407Negative regulation of MAP kinase activityIEAbiological_process
GO:0043539Protein serine/threonine kinase activator activityIMPmolecular_function
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0046580Negative regulation of Ras protein signal transductionIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0051387Negative regulation of neurotrophin TRK receptor signaling pathwayIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0060425Lung morphogenesisIEAbiological_process
GO:0060437Lung growthIEAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00022192170.37946353100.04326814811.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8866933098
GSE13712_SHEARUp0.6204841738
GSE13712_STATICUp0.5184690840
GSE19018Down-1.3832301442
GSE19899_A1Up3.0927585590
GSE19899_A2Up1.7367067623
PubMed_21979375_A1Up2.4572543962
PubMed_21979375_A2Up1.8499561599
GSE35957Up0.1349898379
GSE36640Up0.6965577317
GSE54402Up3.0743071048
GSE9593Up0.6494010550
GSE43922Up1.1237141469
GSE24585Down-0.6115215482
GSE37065Up0.9468960769
GSE28863_A1Down-0.2216438502
GSE28863_A2Up0.3684610100
GSE28863_A3Down-0.6876971224
GSE28863_A4Up0.3216928439
GSE48662Down-0.3792606043

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT000672Luciferase reporter assayFunctional MTI18508928
hsa-miR-21-5pMIMAT0000076MIRT000672Luciferase reporter assay//qRT-PCRFunctional MTI21278789
hsa-miR-21-5pMIMAT0000076MIRT000672Luciferase reporter assayFunctional MTI23239100
hsa-miR-27a-3pMIMAT0000084MIRT005511Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20638779
hsa-miR-124-3pMIMAT0000422MIRT022159MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023487MicroarrayFunctional MTI (Weak)18668037
hsa-miR-181a-5pMIMAT0000256MIRT025117SequencingFunctional MTI (Weak)20371350
hsa-miR-148a-3pMIMAT0000243MIRT025980SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT028756MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.