HCSGD entry for SPRY1
1. General information
| Official gene symbol | SPRY1 |
|---|---|
| Entrez ID | 10252 |
| Gene full name | sprouty homolog 1, antagonist of FGF signaling (Drosophila) |
| Other gene symbols | hSPRY1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001656 | Metanephros development | IEA | biological_process |
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0001759 | Organ induction | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0034261 | Negative regulation of Ras GTPase activity | IEA | biological_process |
| GO:0040037 | Negative regulation of fibroblast growth factor receptor signaling pathway | IEA | biological_process |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0043407 | Negative regulation of MAP kinase activity | IEA | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0051387 | Negative regulation of neurotrophin TRK receptor signaling pathway | IEA | biological_process |
| GO:0070373 | Negative regulation of ERK1 and ERK2 cascade | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1275266973 | 0.0325727138 | 0.7269485170 | 0.3404870532 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3364597076 |
| GSE13712_SHEAR | Down | -1.0554268715 |
| GSE13712_STATIC | Down | -1.2985005264 |
| GSE19018 | Up | 0.3771379975 |
| GSE19899_A1 | Down | -0.4700216940 |
| GSE19899_A2 | Down | -0.4918521547 |
| PubMed_21979375_A1 | Up | 0.4539634623 |
| PubMed_21979375_A2 | Up | 1.1604697943 |
| GSE35957 | Up | 0.0254523365 |
| GSE36640 | Up | 0.3176506897 |
| GSE54402 | Down | -0.9690161717 |
| GSE9593 | Up | 0.0280982516 |
| GSE43922 | Up | 0.0923591524 |
| GSE24585 | Down | -0.6293203928 |
| GSE37065 | Down | -0.2528659659 |
| GSE28863_A1 | Up | 0.7878852802 |
| GSE28863_A2 | Up | 0.9526973519 |
| GSE28863_A3 | Up | 0.0425554904 |
| GSE28863_A4 | Down | -0.0535939994 |
| GSE48662 | Up | 0.3999886035 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027552 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029134 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042959 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3615 | MIMAT0017994 | MIRT052850 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27000748 | DNA hypomethylation at the SPRY1 gene locus downregulates sprouty1, causing inability to maintain quiescence and eventual exhaustion of the stem cell population |
| 26526994 | Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle |
| 26526994 | We link aging to an increased methylation of the SPRY1 gene, a known regulator of muscle stem cell quiescence |
| 26526994 | Replenishment of the reserve cell pool was modulated experimentally by demethylation or siRNA knockdown of SPRY1 |
| 26526994 | We propose that suppression of SPRY1 by age-associated methylation in humans inhibits the replenishment of the muscle stem cell pool, contributing to a decreased regenerative response in old age |
| 24270409 | In the present work, we describe a novel mechanism by which Spry1 restricts proliferation, independently of the ERK pathway |
| 24270409 | In vivo analysis of thyroid glands from Spry1 knockout mice reveals that Spry1 induces a senescence-associated secretory phenotype via activation of the NFkappaB pathway |
| 24270409 | Consistently, thyroids from Spry1 knockout mice are bigger and exhibit decreased markers of senescence including Ki67 labeling and senescence-associated beta-galactosidase |
| 24270409 | Although such 'escape' from senescence is not sufficient to promote thyroid tumorigenesis in adult mice up to 5 months, the onset of Phosphatase and tensin homolog (Pten)-induced tumor formation is accelerated when Spry1 is concomitantly eliminated |
| 24270409 | Accordingly, we observe a reduction of SPRY1 levels in human thyroid malignancies when compared with non-tumoral tissue |
| 24270409 | We propose that Spry1 acts as a sensor of mitogenic activity that not only attenuates RTK signaling but also induces a cellular senescence response to avoid uncontrolled proliferation |
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