HCSGD entry for CDK8
1. General information
| Official gene symbol | CDK8 |
|---|---|
| Entrez ID | 1024 |
| Gene full name | cyclin-dependent kinase 8 |
| Other gene symbols | K35 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016592 | Mediator complex | IDA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6625933361 | 0.5255076631 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1153702965 |
| GSE13712_SHEAR | Up | 0.2150718110 |
| GSE13712_STATIC | Up | 0.0451443713 |
| GSE19018 | Down | -0.2158311086 |
| GSE19899_A1 | Down | -0.1911021736 |
| GSE19899_A2 | Up | 0.3026858437 |
| PubMed_21979375_A1 | Up | 0.5458827807 |
| PubMed_21979375_A2 | Up | 0.2888436626 |
| GSE35957 | Down | -0.1590130323 |
| GSE36640 | Down | -0.2893811479 |
| GSE54402 | Up | 0.1943616511 |
| GSE9593 | Down | -0.0015999258 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0519143739 |
| GSE28863_A2 | Down | -0.0705030515 |
| GSE28863_A3 | Down | -0.2417591612 |
| GSE28863_A4 | Up | 0.1309516596 |
| GSE48662 | Down | -0.5321032302 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Flavopiridol | DB03496 | EXPT00998 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT001021 | Western blot | Non-Functional MTI | 18713946 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041203 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047736 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
