HCSGD entry for TRIB1
1. General information
| Official gene symbol | TRIB1 |
|---|---|
| Entrez ID | 10221 |
| Gene full name | tribbles homolog 1 (Drosophila) |
| Other gene symbols | C8FW GIG2 SKIP1 TRB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004860 | Protein kinase inhibitor activity | IMP | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | IMP | biological_process |
| GO:0007254 | JNK cascade | IMP | biological_process |
| GO:0008134 | Transcription factor binding | IEA IPI | molecular_function |
| GO:0014912 | Negative regulation of smooth muscle cell migration | IMP | biological_process |
| GO:0031434 | Mitogen-activated protein kinase kinase binding | IDA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IEA ISS | molecular_function |
| GO:0031665 | Negative regulation of lipopolysaccharide-mediated signaling pathway | IMP | biological_process |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA IMP ISS | biological_process |
| GO:0043405 | Regulation of MAP kinase activity | IDA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IEA IMP ISS | biological_process |
| GO:0048662 | Negative regulation of smooth muscle cell proliferation | IMP | biological_process |
| GO:0055106 | Ubiquitin-protein ligase regulator activity | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0025777630 | 0.6328245697 | 0.1381418699 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0430872388 |
| GSE13712_SHEAR | Up | 0.4316455099 |
| GSE13712_STATIC | Up | 0.3094660564 |
| GSE19018 | Down | -0.4588885418 |
| GSE19899_A1 | Up | 1.2909992339 |
| GSE19899_A2 | Up | 0.9377277459 |
| PubMed_21979375_A1 | Up | 1.6612797343 |
| PubMed_21979375_A2 | Up | 1.5355333821 |
| GSE35957 | Down | -0.1010808054 |
| GSE36640 | Up | 0.2465054187 |
| GSE54402 | Up | 1.2748340623 |
| GSE9593 | Up | 0.3244036797 |
| GSE43922 | Up | 1.6779466016 |
| GSE24585 | Down | -0.7572201938 |
| GSE37065 | Up | 0.6194197338 |
| GSE28863_A1 | Down | -0.1618679998 |
| GSE28863_A2 | Up | 0.3445231564 |
| GSE28863_A3 | Down | -0.6870856590 |
| GSE28863_A4 | Down | -0.0566860045 |
| GSE48662 | Up | 0.2593578051 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003109 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016950 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT027398 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027499 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028892 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
