HCSGD entry for KLRG1
1. General information
| Official gene symbol | KLRG1 |
|---|---|
| Entrez ID | 10219 |
| Gene full name | killer cell lectin-like receptor subfamily G, member 1 |
| Other gene symbols | 2F1 CLEC15A MAFA MAFA-2F1 MAFA-L MAFA-LIKE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0006968 | Cellular defense response | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0045087 | Innate immune response | IEA | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9058488811 | 0.1069598837 | 0.9999902473 | 0.6260376028 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0322355674 |
| GSE13712_SHEAR | Down | -1.1060818451 |
| GSE13712_STATIC | Down | -3.4374192100 |
| GSE19018 | Up | 0.1790547941 |
| GSE19899_A1 | Up | 0.0604368012 |
| GSE19899_A2 | Up | 0.0550931413 |
| PubMed_21979375_A1 | Down | -0.0736129480 |
| PubMed_21979375_A2 | Down | -0.1458749154 |
| GSE35957 | Down | -0.2035450955 |
| GSE36640 | Up | 0.2752418062 |
| GSE54402 | Up | 0.0294909942 |
| GSE9593 | Down | -0.2001440346 |
| GSE43922 | Down | -0.0484988450 |
| GSE24585 | Down | -0.0288758983 |
| GSE37065 | Down | -0.0173388412 |
| GSE28863_A1 | Up | 0.0325881935 |
| GSE28863_A2 | Up | 0.1416553243 |
| GSE28863_A3 | Up | 0.0362551201 |
| GSE28863_A4 | Up | 0.0607977225 |
| GSE48662 | Up | 0.0975113321 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT036992 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22396780 | Instead a set of surface markers including IL-7Ralpha and KLRG1 is commonly used to predict the potential of CD8 effector T cells to differentiate into memory cells |
| 22102004 | Using five-colour flow cytometry, we analyzed peripheral blood T-lymphocytes for their expression of CD28, CD57 and KLRG1 in 11 young (Y) and 11 old (O) apparently healthy human subjects |
| 19479342 | The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence |
| 19479342 | Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging indicating that KLRG1 plays an inhibitory role |
| 19479342 | In this review we examine evidence highlighting this view of KLRG1 with emphasis on the functional defects that arise during T cell differentiation with age that may, in part, be actively maintained by inhibitory receptor signalling |
| 17379755 | As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further antigenic stimulation, and express the killer cell lectin-like receptor G1 (KLRG1) and/or CD57 |
| 17379755 | Blood lymphocytes isolated before, immediately after, and 1 h after exercise were assessed for cell surface expression of KLRG1, CD57, CD28, CD45RA, CD45RO, CD62L, and lymphocyte subset markers (CD3, CD4, CD8, CD56) by flow cytometry |
| 17379755 | The percentage of all CD3+ T lymphocytes expressing KLRG1 and CD57 increased with exercise (P < 0 |
| 17379755 | The change in T-lymphocyte KLRG1 expression was attributed to both CD4+ and CD8 bright T cells, with the relative change being greater for the CD8 bright population (P < 0 |
| 17379755 | Mobilized T-lymphocyte populations expressing KLRG1 and CD57 appeared to extravasate the peripheral blood compartment after 1 h of recovery |
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