HCSGD entry for OLIG2

1. General information

Official gene symbolOLIG2
Entrez ID10215
Gene full nameoligodendrocyte lineage transcription factor 2
Other gene symbolsBHLHB1 OLIGO2 PRKCBP2 RACK17 bHLHe19
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0021522Spinal cord motor neuron differentiationIEAbiological_process
GO:0021530Spinal cord oligodendrocyte cell fate specificationIEAbiological_process
GO:0021794Thalamus developmentIEAbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.50403138560.93479150490.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1306213324
GSE13712_SHEARDown-0.0800224087
GSE13712_STATICUp0.0182428685
GSE19018Up0.2036297161
GSE19899_A1Down-0.0123521573
GSE19899_A2Down-0.0050781131
PubMed_21979375_A1Up0.1219131541
PubMed_21979375_A2Up0.1103470176
GSE35957Up0.0385506586
GSE36640Up0.0170742172
GSE54402Up0.0011509298
GSE9593Up0.0387404832
GSE43922Up0.1323939815
GSE24585Up0.0215704136
GSE37065Up0.0617457676
GSE28863_A1Down-0.0993314309
GSE28863_A2Down-0.0284327844
GSE28863_A3Up0.2632297076
GSE28863_A4Up0.0779531522
GSE48662Up0.0151533799

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-218-5pMIMAT0000275MIRT024220SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26896279Once formed, tumor organoids grew for months and displayed regional heterogeneity with a rapidly dividing outer region of SOX2(+), OLIG2(+), and TLX(+) cells surrounding a hypoxic core of primarily non-stem senescent cells and diffuse, quiescent CSCs
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