HCSGD entry for NUTF2
1. General information
| Official gene symbol | NUTF2 |
|---|---|
| Entrez ID | 10204 |
| Gene full name | nuclear transport factor 2 |
| Other gene symbols | NTF2 PP15 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006611 | Protein export from nucleus | IDA | biological_process |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9437991072 | 0.0533757342 | 0.9999902473 | 0.4354937074 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0362365028 |
| GSE13712_SHEAR | Down | -0.0442049621 |
| GSE13712_STATIC | Down | -0.1244281119 |
| GSE19018 | Up | 0.0345943263 |
| GSE19899_A1 | Down | -0.2470361619 |
| GSE19899_A2 | Down | -0.4261694371 |
| PubMed_21979375_A1 | Down | -0.5668326225 |
| PubMed_21979375_A2 | Down | -0.7978363742 |
| GSE35957 | Up | 0.3216770036 |
| GSE36640 | Up | 0.2619510785 |
| GSE54402 | Down | -0.2763949088 |
| GSE9593 | Up | 0.2808377649 |
| GSE43922 | Up | 0.0034274173 |
| GSE24585 | Down | -0.4705164129 |
| GSE37065 | Down | -0.2363425376 |
| GSE28863_A1 | Down | -0.2322024842 |
| GSE28863_A2 | Down | -0.2430236054 |
| GSE28863_A3 | Up | 0.0601549768 |
| GSE28863_A4 | Up | 0.0313326187 |
| GSE48662 | Down | -0.1559493279 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036033 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT050639 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21195711 | Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells |
| 21195711 | Failure of RanGTP restoration was accompanied with inhibition of ATP synthesis and NTF2 sequestration in the nuclei along with accordant change of senescence morphology |
| 21195711 | Therefore, actin accumulation in nuclei of senescent cells is most likely due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation in nuclei, which result in the decrease of actin export via Exp6 inactivation, in addition to actin import by cofilin activation |
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