HCSGD entry for CDK5

1. General information

Official gene symbolCDK5
Entrez ID1020
Gene full namecyclin-dependent kinase 5
Other gene symbolsPSSALRE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationTASbiological_process
GO:0001963Synaptic transmission, dopaminergicIEAbiological_process
GO:0002039P53 bindingIEAmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA ISS TASmolecular_function
GO:0004693Cyclin-dependent protein serine/threonine kinase activityISSmolecular_function
GO:0005176ErbB-2 class receptor bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0006886Intracellular protein transportIEAbiological_process
GO:0006913Nucleocytoplasmic transportIEAbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007416Synapse assemblyTASbiological_process
GO:0007519Skeletal muscle tissue developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008045Motor neuron axon guidanceIEAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0010469Regulation of receptor activityISSbiological_process
GO:0014044Schwann cell developmentIEAbiological_process
GO:0014069Postsynaptic densityISScellular_component
GO:0016020MembraneISScellular_component
GO:0016079Synaptic vesicle exocytosisTASbiological_process
GO:0016301Kinase activityISSmolecular_function
GO:0016310PhosphorylationIDAbiological_process
GO:0016533Cyclin-dependent protein kinase 5 holoenzyme complexIEAcellular_component
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIEAbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0021697Cerebellar cortex formationIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021819Layer formation in cerebral cortexIEAbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0022038Corpus callosum developmentIEAbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030175FilopodiumIEAcellular_component
GO:0030182Neuron differentiationISS TASbiological_process
GO:0030334Regulation of cell migrationIEAbiological_process
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0030426Growth coneISScellular_component
GO:0030517Negative regulation of axon extensionIEAbiological_process
GO:0030549Acetylcholine receptor activator activityISSmolecular_function
GO:0030866Cortical actin cytoskeleton organizationIEAbiological_process
GO:0031175Neuron projection developmentISSbiological_process
GO:0031397Negative regulation of protein ubiquitinationIEAbiological_process
GO:0031594Neuromuscular junctionISScellular_component
GO:0031914Negative regulation of synaptic plasticityIEAbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032801Receptor catabolic processIEAbiological_process
GO:0033136Serine phosphorylation of STAT3 proteinIEAbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0035418Protein localization to synapseIEAbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0043113Receptor clusteringIEAbiological_process
GO:0043125ErbB-3 class receptor bindingISSmolecular_function
GO:0043204PerikaryonIEAcellular_component
GO:0043525Positive regulation of neuron apoptotic processISSbiological_process
GO:0045055Regulated secretory pathwayIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045786Negative regulation of cell cycleIEAbiological_process
GO:0045860Positive regulation of protein kinase activityIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045956Positive regulation of calcium ion-dependent exocytosisIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0046826Negative regulation of protein export from nucleusIEAbiological_process
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048148Behavioral response to cocaineIEAbiological_process
GO:0048167Regulation of synaptic plasticityISS TASbiological_process
GO:0048488Synaptic vesicle endocytosisTASbiological_process
GO:0048675Axon extensionTASbiological_process
GO:0048709Oligodendrocyte differentiationIDAbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0050321Tau-protein kinase activityISSmolecular_function
GO:0051301Cell divisionIEAbiological_process
GO:0051402Neuron apoptotic processTASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0061001Regulation of dendritic spine morphogenesisISSbiological_process
GO:0070509Calcium ion importIEAbiological_process
GO:0071156Regulation of cell cycle arrestTASbiological_process
GO:0090314Positive regulation of protein targeting to membraneIEAbiological_process
GO:2000251Positive regulation of actin cytoskeleton reorganizationTASbiological_process
GO:2000273Positive regulation of receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31244807950.09533374870.99999024730.5884802064

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7283351266
GSE13712_SHEARDown-0.4771596025
GSE13712_STATICDown-0.4116114027
GSE19018Up0.2939463953
GSE19899_A1Down-0.0083413569
GSE19899_A2Up0.2599720628
PubMed_21979375_A1Up0.5351868287
PubMed_21979375_A2Up0.3163020130
GSE35957Down-0.3799625528
GSE36640Down-0.0159030745
GSE54402Up0.1537566760
GSE9593Up0.2895925862
GSE43922Down-0.0192404712
GSE24585Down-0.1129166380
GSE37065Up0.3237688261
GSE28863_A1Down-0.4809024480
GSE28863_A2Down-0.3914730539
GSE28863_A3Down-0.6125973228
GSE28863_A4Down-0.1670332795
GSE48662Up0.0165327161

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL428690CHEMBL40369Q00535
CHEMBL296468CHEMBL40369Q00535
CHEMBL574738CHEMBL40369Q00535
CHEMBL428690CHEMBL40369Q00535
CHEMBL574738CHEMBL40369Q00535
CHEMBL103667CHEMBL40369Q00535
CHEMBL235764CHEMBL40369Q00535
CHEMBL1336CHEMBL40369Q00535
CHEMBL509032CHEMBL40369Q00535
CHEMBL191003CHEMBL40369Q00535
CHEMBL103667CHEMBL40369Q00535
CHEMBL445813CHEMBL40369Q00535
CHEMBL240799CHEMBL40369Q00535
CHEMBL162CHEMBL40369Q00535
CHEMBL535CHEMBL40369Q00535
CHEMBL384304CHEMBL40369Q00535
CHEMBL296468CHEMBL40369Q00535
CHEMBL577030CHEMBL40369Q00535
CHEMBL162CHEMBL40369Q00535
CHEMBL603469CHEMBL40369Q00535
CHEMBL14762CHEMBL40369Q00535
CHEMBL563962CHEMBL40369Q00535
CHEMBL103667CHEMBL40369Q00535
CHEMBL564921CHEMBL40369Q00535
CHEMBL14762CHEMBL40369Q00535
CHEMBL428690CHEMBL40369Q00535
CHEMBL550658CHEMBL40369Q00535
CHEMBL1336CHEMBL40369Q00535
CHEMBL162CHEMBL40369Q00535
CHEMBL552324CHEMBL40369Q00535
CHEMBL186240CHEMBL40368Q00535
CHEMBL187015CHEMBL40368Q00535
CHEMBL363711CHEMBL40368Q00535
CHEMBL427901CHEMBL40368Q00535
CHEMBL364338CHEMBL40368Q00535
CHEMBL14762CHEMBL40368Q00535
CHEMBL185470CHEMBL40368Q00535
CHEMBL186470CHEMBL40368Q00535
CHEMBL426972CHEMBL40368Q00535
CHEMBL186847CHEMBL40368Q00535
CHEMBL363252CHEMBL40368Q00535
CHEMBL225519CHEMBL40368Q00535
CHEMBL186510CHEMBL40368Q00535
CHEMBL186846CHEMBL40368Q00535
CHEMBL185734CHEMBL40368Q00535
CHEMBL365855CHEMBL40368Q00535
CHEMBL186342CHEMBL40368Q00535
CHEMBL603469CHEMBL40368Q00535
CHEMBL186932CHEMBL40368Q00535
CHEMBL364213CHEMBL40368Q00535
CHEMBL363283CHEMBL40368Q00535
CHEMBL186371CHEMBL40368Q00535
CHEMBL186511CHEMBL40368Q00535
CHEMBL187256CHEMBL40368Q00535
CHEMBL186934CHEMBL40368Q00535
CHEMBL434917CHEMBL40368Q00535
CHEMBL363954CHEMBL40368Q00535
CHEMBL186201CHEMBL40368Q00535
CHEMBL362369CHEMBL40368Q00535
CHEMBL188172CHEMBL40368Q00535
CHEMBL187903CHEMBL40368Q00535
CHEMBL359591CHEMBL40368Q00535
CHEMBL184404CHEMBL40368Q00535
CHEMBL186898CHEMBL40368Q00535
CHEMBL1080583CHEMBL40368Q00535
CHEMBL185498CHEMBL40368Q00535
CHEMBL186120CHEMBL40368Q00535
CHEMBL131041CHEMBL40368Q00535
CHEMBL1092509CHEMBL40368Q00535
CHEMBL280623CHEMBL40368Q00535
CHEMBL131668CHEMBL40368Q00535
CHEMBL282193CHEMBL40368Q00535
CHEMBL130113CHEMBL40368Q00535
CHEMBL362560CHEMBL40368Q00535
CHEMBL131041CHEMBL40368Q00535
CHEMBL131031CHEMBL40368Q00535
CHEMBL280074CHEMBL40368Q00535
CHEMBL1242831CHEMBL40368Q00535
CHEMBL131697CHEMBL40368Q00535
CHEMBL336537CHEMBL40368Q00535
CHEMBL564829CHEMBL40368Q00535
CHEMBL133461CHEMBL40368Q00535
CHEMBL26564CHEMBL40368Q00535
CHEMBL14762CHEMBL40368Q00535
CHEMBL422759CHEMBL40368Q00535
CHEMBL130597CHEMBL40368Q00535
CHEMBL1081198CHEMBL40368Q00535
CHEMBL1241935CHEMBL40368Q00535
CHEMBL444169CHEMBL40368Q00535
CHEMBL50894CHEMBL40368Q00535
CHEMBL75680CHEMBL40368Q00535
CHEMBL23317CHEMBL40368Q00535
CHEMBL440717CHEMBL40368Q00535
CHEMBL129922CHEMBL40368Q00535
CHEMBL286491CHEMBL40368Q00535
CHEMBL409450CHEMBL40368Q00535
CHEMBL284899CHEMBL40368Q00535
CHEMBL334339CHEMBL40368Q00535
CHEMBL280074CHEMBL40368Q00535
CHEMBL130113CHEMBL40368Q00535
CHEMBL335966CHEMBL40368Q00535
CHEMBL133770CHEMBL40368Q00535
CHEMBL133533CHEMBL40368Q00535
CHEMBL25840CHEMBL40368Q00535
CHEMBL258805CHEMBL40368Q00535
CHEMBL131668CHEMBL40368Q00535
CHEMBL518732CHEMBL40368Q00535
CHEMBL23525CHEMBL40368Q00535
CHEMBL1077347CHEMBL40368Q00535
CHEMBL551510CHEMBL40368Q00535
CHEMBL129922CHEMBL40368Q00535
CHEMBL1241758CHEMBL40368Q00535
CHEMBL26513CHEMBL40368Q00535
CHEMBL134890CHEMBL40368Q00535
CHEMBL52387CHEMBL40368Q00535
CHEMBL1082152CHEMBL40368Q00535
CHEMBL50498CHEMBL40368Q00535
CHEMBL115220CHEMBL40368Q00535
CHEMBL476851CHEMBL40368Q00535
CHEMBL24484CHEMBL40368Q00535
CHEMBL281525CHEMBL40368Q00535
CHEMBL1242367CHEMBL40368Q00535
CHEMBL560453CHEMBL40368Q00535
CHEMBL336117CHEMBL40368Q00535
CHEMBL424696CHEMBL40367Q00535
CHEMBL210540CHEMBL40367Q00535
CHEMBL373882CHEMBL40367Q00535
CHEMBL327004CHEMBL40366Q00535
CHEMBL23327CHEMBL40365Q00535
CHEMBL23254CHEMBL40365Q00535
CHEMBL482193CHEMBL40365Q00535
CHEMBL521274CHEMBL40365Q00535
CHEMBL23327CHEMBL40365Q00535
CHEMBL14762CHEMBL40365Q00535
CHEMBL480442CHEMBL40365Q00535
CHEMBL482211CHEMBL40365Q00535
CHEMBL491647CHEMBL40364Q00535
CHEMBL524266CHEMBL40364Q00535
CHEMBL491647CHEMBL40364Q00535
CHEMBL489833CHEMBL40364Q00535
CHEMBL510863CHEMBL40364Q00535
CHEMBL453133CHEMBL40364Q00535
CHEMBL522760CHEMBL40364Q00535
CHEMBL489833CHEMBL40364Q00535
CHEMBL1234833CHEMBL40364Q00535
CHEMBL14762CHEMBL40364Q00535
CHEMBL162CHEMBL40364Q00535
CHEMBL522590CHEMBL40364Q00535
CHEMBL522590CHEMBL40364Q00535
CHEMBL210229CHEMBL40364Q00535
CHEMBL14762CHEMBL40364Q00535
CHEMBL162CHEMBL40364Q00535
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  • Drugs

Name

Drug

Accession number

Indirubin-3'-MonoximeDB02052 EXPT01949
OlomoucineDB02116 EXPT02433
HymenialdisineDB02950 EXPT01757
SU9516DB03428 EXPT02974
FlavopiridolDB03496 EXPT00998
AlsterpaulloneDB04014 EXPT00590
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINEDB07364 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020734ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23968571Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5
23968571A recent study suggests that cyclin-dependent kinase 5 (CDK5) is responsible for the phosphorylation of SIRT1 at the serine 47 residue
23968571Thus, by inhibiting CDK5, SIRT1 function can be improved, in turn preventing the development of atherosclerosis and slowing down the process of vascular ageing
22753194Cyclin-dependent kinase 5 (CDK5) was identified as an SIRT1 kinase modulating S47 phosphorylation
22753194Knockdown or inhibition of CDK5 reduced the number of senescent endothelial cells, promoted nuclear exportation of SIRT1, and attenuated the expression of inflammatory genes in porcine aortic endothelial cells
22753194Long-term treatment with roscovitine, a CDK5 inhibitor, blocked the development of cellular senescence and atherosclerosis in aortas of hypercholesterolemic apolipoprotein E-deficient mice
20181942The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the best known function of which is in neuronal development and postmitotic neuronal activities
20181942Activation of CDK5 in neurons depends on its activators p35 and p39; however, little is known about how CDK5 is activated in non-neuronal senescent cells
20181942Here we report that p35 is required for the activation of CDK5 in the process of cellular senescence
20181942We demonstrate that: (i) p35 is expressed in osteosarcoma cells, (ii) p35 is required for CDK5 activation induced by pRB during senescence, (iii) p35 is required for the senescent morphological changes in which CDK5 is known to be involved as well as for expression of the senescence secretome, and (iv) p35 is up-regulated in senescing cells
20181942Taken together, these results suggest that p35 is at least one of the activators of CDK5 that is mobilized in the process of cellular senescence, which may provide insight into cancer cell proliferation and future cancer therapeutics
16510591Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells
16510591Here, we show that pRb-induced senescent SAOS-2 cells and senescent human diploid fibroblasts are accompanied by increased phosphorylation of ezrin at T235 by cyclin-dependent kinase 5 and consequent dissociation of Rho GDP dissociation inhibitor (Rho-GDI) from an ezrin/Rho-GDI complex
15024070Cellular senescence requires CDK5 repression of Rac1 activity
15024070We report here a role for CDK5 in induction of senescent cytoskeletal changes
15024070CDK5 activation is upregulated in senescing cells
15024070The increased activity of CDK5 further reduces GTPase Rac1 activity and Pak activation
15024070The repression of the activity of the GTPase Rac1 by CDK5 is required for expression of the senescent phenotype
15024070CDK5 regulation of Rac1 activity is necessary for actin polymerization accompanying senescent morphology in response to expression of pRb, activated Ras, or continuous passage
15024070Inhibition of CDK5 attenuates SA-beta-Gal expression and blocks actin polymerization
15024070These results point to a unique, nonneuronal role for CDK5 in regulation of Rac1 activity in senescence, illuminating the mechanisms underlying induction of senescence and the senescent shape change
14504464Cdk5 activity increases in senescing cells and is required for expression of SA-beta-gal and for actin polymerization accompanying acquisition of the senescent morphology
12769842Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
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