HCSGD entry for SORBS3
1. General information
| Official gene symbol | SORBS3 |
|---|---|
| Entrez ID | 10174 |
| Gene full name | sorbin and SH3 domain containing 3 |
| Other gene symbols | SCAM-1 SCAM1 SH3D4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA | cellular_component |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007015 | Actin filament organization | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA TAS | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0017166 | Vinculin binding | IPI | molecular_function |
| GO:0031589 | Cell-substrate adhesion | IEA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0051495 | Positive regulation of cytoskeleton organization | NAS | biological_process |
| GO:0051496 | Positive regulation of stress fiber assembly | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8823970062 | 0.0285068614 | 0.9999902473 | 0.3208411111 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2432706261 |
| GSE13712_SHEAR | Down | -0.2959149098 |
| GSE13712_STATIC | Down | -0.3856192069 |
| GSE19018 | Up | 0.3122430407 |
| GSE19899_A1 | Down | -0.4909239670 |
| GSE19899_A2 | Down | -0.2334231805 |
| PubMed_21979375_A1 | Down | -0.5881435159 |
| PubMed_21979375_A2 | Down | -0.4431752960 |
| GSE35957 | Up | 0.2788368999 |
| GSE36640 | Down | -0.3263549128 |
| GSE54402 | Down | -0.7124387178 |
| GSE9593 | Up | 0.1279754464 |
| GSE43922 | Down | -0.2986101979 |
| GSE24585 | Down | -0.0403529941 |
| GSE37065 | Down | -0.2113210793 |
| GSE28863_A1 | Down | -0.0104405572 |
| GSE28863_A2 | Up | 0.1438623232 |
| GSE28863_A3 | Up | 0.1328080657 |
| GSE28863_A4 | Down | -0.0672129254 |
| GSE48662 | Up | 0.1396197684 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037354 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037629 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
