HCSGD entry for FARP1
1. General information
| Official gene symbol | FARP1 |
|---|---|
| Entrez ID | 10160 |
| Gene full name | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
| Other gene symbols | CDEP PLEKHC2 PPP1R75 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA TAS | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0007416 | Synapse assembly | IEA ISS | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0010923 | Negative regulation of phosphatase activity | IDA | biological_process |
| GO:0019898 | Extrinsic component of membrane | IEA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030175 | Filopodium | IEA | cellular_component |
| GO:0030425 | Dendrite | IEA ISS | cellular_component |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | IEA ISS | molecular_function |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IEA ISS | cellular_component |
| GO:0032314 | Regulation of Rac GTPase activity | ISS | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | ISS TAS | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | ISS TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | ISS TAS | biological_process |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0048365 | Rac GTPase binding | IEA | molecular_function |
| GO:0048813 | Dendrite morphogenesis | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9818135367 | 0.0196124501 | 0.9999902473 | 0.2729747491 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3150474284 |
| GSE13712_SHEAR | Down | -0.1101903477 |
| GSE13712_STATIC | Down | -0.1896771649 |
| GSE19018 | Down | -0.2082512579 |
| GSE19899_A1 | Down | -0.8921090768 |
| GSE19899_A2 | Down | -0.1107863992 |
| PubMed_21979375_A1 | Down | -0.4702915292 |
| PubMed_21979375_A2 | Up | 0.1948831529 |
| GSE35957 | Up | 0.0002312953 |
| GSE36640 | Up | 0.1648309087 |
| GSE54402 | Down | -0.4603733195 |
| GSE9593 | Down | -0.2158693686 |
| GSE43922 | Down | -0.7389684837 |
| GSE24585 | Down | -0.0663358119 |
| GSE37065 | Down | -0.3751289645 |
| GSE28863_A1 | Down | -0.1062810876 |
| GSE28863_A2 | Down | -0.5126610146 |
| GSE28863_A3 | Up | 0.0326305657 |
| GSE28863_A4 | Up | 0.0044666956 |
| GSE48662 | Up | 0.0286450144 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005052 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005826 | Microarray | Functional MTI (Weak) | 21282569 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023200 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030304 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
