HCSGD entry for TRIM28
1. General information
| Official gene symbol | TRIM28 |
|---|---|
| Entrez ID | 10155 |
| Gene full name | tripartite motif containing 28 |
| Other gene symbols | KAP1 RNF96 TF1B TIF1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001837 | Epithelial to mesenchymal transition | IEA ISS | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA ISS | molecular_function |
| GO:0003713 | Transcription coactivator activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005654 | Nucleoplasm | IEA TAS | cellular_component |
| GO:0005719 | Nuclear euchromatin | IEA | cellular_component |
| GO:0005720 | Nuclear heterochromatin | IEA | cellular_component |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0016925 | Protein sumoylation | IDA IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0035851 | Krueppel-associated box domain binding | IDA | molecular_function |
| GO:0042993 | Positive regulation of transcription factor import into nucleus | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA ISS | molecular_function |
| GO:0045739 | Positive regulation of DNA repair | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0051259 | Protein oligomerization | IDA | biological_process |
| GO:0060028 | Convergent extension involved in axis elongation | IEA | biological_process |
| GO:0060669 | Embryonic placenta morphogenesis | IEA | biological_process |
| GO:0070087 | Chromo shadow domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7859853653 | 0.0545838000 | 0.9999902473 | 0.4407055828 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2212025851 |
| GSE13712_SHEAR | Down | -0.2032598007 |
| GSE13712_STATIC | Down | -0.0775347622 |
| GSE19018 | Down | -0.0823603968 |
| GSE19899_A1 | Down | -0.5327217432 |
| GSE19899_A2 | Down | -0.2676606227 |
| PubMed_21979375_A1 | Up | 1.0972611511 |
| PubMed_21979375_A2 | Up | 0.6884747744 |
| GSE35957 | Down | -0.8136207261 |
| GSE36640 | Down | -0.7318459120 |
| GSE54402 | Down | -0.0921763949 |
| GSE9593 | Down | -0.4228352022 |
| GSE43922 | Down | -0.1761082940 |
| GSE24585 | Down | -0.2732002168 |
| GSE37065 | Down | -0.2540823815 |
| GSE28863_A1 | Up | 0.0964493431 |
| GSE28863_A2 | Up | 0.1567242274 |
| GSE28863_A3 | Down | -0.4480704372 |
| GSE28863_A4 | Down | -0.0118279029 |
| GSE48662 | Up | 0.0439123859 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037068 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037599 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-5p | MIMAT0004776 | MIRT037943 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038141 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038878 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041001 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041271 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041711 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045571 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046915 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047101 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049953 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051347 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052068 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
