HCSGD entry for TOB1
1. General information
| Official gene symbol | TOB1 |
|---|---|
| Entrez ID | 10140 |
| Gene full name | transducer of ERBB2, 1 |
| Other gene symbols | APRO6 PIG49 TOB TROB TROB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0017148 | Negative regulation of translation | IDA | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0030971 | Receptor tyrosine kinase binding | IDA | molecular_function |
| GO:0060212 | Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening | IDA | biological_process |
| GO:0060213 | Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | IDA | biological_process |
| GO:1900153 | Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0092267391 | 0.5508166711 | 0.2460557244 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2764725861 |
| GSE13712_SHEAR | Up | 0.4922316980 |
| GSE13712_STATIC | Up | 0.6022786514 |
| GSE19018 | Up | 0.8288306667 |
| GSE19899_A1 | Down | -0.5250833537 |
| GSE19899_A2 | Up | 0.4370714943 |
| PubMed_21979375_A1 | Down | -0.8960444783 |
| PubMed_21979375_A2 | Down | -0.5177342786 |
| GSE35957 | Up | 0.6650196341 |
| GSE36640 | Up | 1.5563896873 |
| GSE54402 | Down | -0.5456656492 |
| GSE9593 | Up | 0.4153648054 |
| GSE43922 | Down | -0.1511584087 |
| GSE24585 | Up | 0.9366740799 |
| GSE37065 | Up | 0.3242104063 |
| GSE28863_A1 | Up | 0.0174302008 |
| GSE28863_A2 | Up | 0.0717814422 |
| GSE28863_A3 | Down | -0.4007055881 |
| GSE28863_A4 | Up | 0.2303266683 |
| GSE48662 | Up | 0.4105767230 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT007049 | Luciferase reporter assay | Functional MTI | 23060446 |
| hsa-miR-641 | MIMAT0003311 | MIRT039574 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050970 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
