HCSGD entry for NAMPT

1. General information

Official gene symbolNAMPT
Entrez ID10135
Gene full namenicotinamide phosphoribosyltransferase
Other gene symbols1110035O14Rik PBEF PBEF1 VF VISFATIN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004514Nicotinate-nucleotide diphosphorylase (carboxylating) activityIEAmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0006769Nicotinamide metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0008286Insulin receptor signaling pathwayIDAbiological_process
GO:0009435NAD biosynthetic processIEAbiological_process
GO:0019674NAD metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0047280Nicotinamide phosphoribosyltransferase activityIEAmolecular_function
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processIDAbiological_process
GO:0060612Adipose tissue developmentIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00076719730.84956517610.07759157091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6402280332
GSE13712_SHEARUp0.0530326932
GSE13712_STATICUp0.1190548330
GSE19018Down-0.4813935323
GSE19899_A1Up2.2743086321
GSE19899_A2Up3.4116487143
PubMed_21979375_A1Up3.6644811213
PubMed_21979375_A2Up3.3894073941
GSE35957Down-0.7339840783
GSE36640Down-0.1428659323
GSE54402Up1.1015783503
GSE9593Up0.3316574292
GSE43922Up1.6272169024
GSE24585Down-0.2194233117
GSE37065Up0.9857618058
GSE28863_A1Up0.0258806736
GSE28863_A2Up0.2641260500
GSE28863_A3Down-0.1909903880
GSE28863_A4Up0.0098989002
GSE48662Up0.0159273201

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1762233CHEMBL17445259P43490
CHEMBL566757CHEMBL17445259P43490
CHEMBL568305CHEMBL17445258P43490
CHEMBL123756CHEMBL17445258P43490
CHEMBL1801866CHEMBL17445258P43490
CHEMBL1801553CHEMBL17445258P43490
CHEMBL1801870CHEMBL17445258P43490
CHEMBL1801936CHEMBL17445258P43490
CHEMBL1801857CHEMBL17445258P43490
CHEMBL1801559CHEMBL17445258P43490
CHEMBL1801867CHEMBL17445258P43490
CHEMBL1801567CHEMBL17445258P43490
CHEMBL1801558CHEMBL17445258P43490
CHEMBL1801937CHEMBL17445258P43490
CHEMBL1801561CHEMBL17445258P43490
CHEMBL1801564CHEMBL17445258P43490
CHEMBL1801933CHEMBL17445258P43490
CHEMBL1801854CHEMBL17445258P43490
CHEMBL1801563CHEMBL17445258P43490
CHEMBL1801562CHEMBL17445258P43490
CHEMBL1801871CHEMBL17445258P43490
CHEMBL1801551CHEMBL17445258P43490
CHEMBL1801863CHEMBL17445258P43490
CHEMBL1801556CHEMBL17445258P43490
CHEMBL1801938CHEMBL17445258P43490
CHEMBL1801855CHEMBL17445258P43490
CHEMBL1801547CHEMBL17445258P43490
CHEMBL1801570CHEMBL17445258P43490
CHEMBL1801869CHEMBL17445258P43490
CHEMBL1801560CHEMBL17445258P43490
CHEMBL1801856CHEMBL17445258P43490
CHEMBL1801865CHEMBL17445258P43490
CHEMBL1801550CHEMBL17445258P43490
CHEMBL1801566CHEMBL17445258P43490
CHEMBL1801571CHEMBL17445258P43490
CHEMBL1801861CHEMBL17445258P43490
CHEMBL1801565CHEMBL17445258P43490
CHEMBL1801552CHEMBL17445258P43490
CHEMBL1801568CHEMBL17445258P43490
CHEMBL1801934CHEMBL17445258P43490
CHEMBL1801549CHEMBL17445258P43490
CHEMBL1801864CHEMBL17445258P43490
CHEMBL1801548CHEMBL17445258P43490
CHEMBL1801569CHEMBL17445258P43490
CHEMBL1801935CHEMBL17445258P43490
CHEMBL1801860CHEMBL17445258P43490
CHEMBL1801555CHEMBL17445258P43490
CHEMBL1801940CHEMBL17445258P43490
CHEMBL1801862CHEMBL17445258P43490
CHEMBL1801941CHEMBL17445258P43490
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  • Drugs

Name

Drug

Accession number

GMX1777DB05217 -
N-[4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL]-3-PYRIDIN-3-YLPROPANAMIDEDB07656 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT005102MicroarrayFunctional MTI (Weak)19193853
hsa-miR-16-5pMIMAT0000069MIRT031598ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26330291A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling
26330291FK866 (a Nampt inhibitor) can reduce intracellular NAD(+) level and induce senescence of human Hs68 cells
26330291In contrast, the protein expression of SIRT1, AMP-activated protein kinase, mammalian target of rapamycin, and nicotinamide phosphoribosyltransferase (Nampt) was not affected by FK866
24727683The intracellular nicotinamide phosphoribosyltransferase (iNampt) activity, cellular NAD()/NADPH ratio and Sirt1 activity were analyzed according to a colorimetric assay to determine the mechanism of cellular senescence
22704488Nampt is involved in DNA double-strand break repair
22704488Nicotinamide phosphoribosyltransferase (Nampt), which is involved in nicotinamide adenine dinucleotide metabolism, is overexpressed in a variety of tumors
22704488In this report, we found that Nampt physically associated with CtIP and DNA-PKcs/Ku80, which are key factors in HR and NHEJ, respectively
22704488Depletion of Nampt by small interfering RNA (siRNA) led to defective NHEJ-mediated DSB repair and enhanced HR-mediated repair
22704488Furthermore, the inhibition of Nampt expression promoted proliferation of cancer cells and normal human fibroblasts and decreased beta-galactosidase staining, indicating a delay in the onset of cellular senescence in normal human fibroblasts
22704488Taken together, our results suggest that Nampt is a suppressor of HR-mediated DSB repair and an enhancer of NHEJ-mediated DSB repair, contributing to the acceleration of cellular senescence
22283774Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions
22190494The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
22190494Activation of a conditional c-MYC allele induced increased levels of SIRT1 protein, NAD(+), and nicotinamide-phosphoribosyltransferase (NAMPT) mRNA in several cell types
22190494This increase in SIRT1 required the induction of the NAMPT gene by c-MYC
22190494NAMPT is the rate-limiting enzyme of the NAD(+) salvage pathway and enhances SIRT1 activity by increasing the amount of NAD(+)
18096661Visfatin, an adipokine hormone produced primarily by visceral adipose tissue in mammals, has been implicated in the immune system, cellular aging, and glucose metabolism
18096661Visfatin mRNA and protein quantities were not significantly different among sc and visceral adipose tissue depots
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