HCSGD entry for RASGRP1

1. General information

Official gene symbolRASGRP1
Entrez ID10125
Gene full nameRAS guanyl releasing protein 1 (calcium and DAG-regulated)
Other gene symbolsCALDAG-GEFI CALDAG-GEFII RASGRP V hRasGRP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0001816Cytokine productionIEAbiological_process
GO:0002437Inflammatory response to antigenic stimulusIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIEA TASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008289Lipid bindingTASmolecular_function
GO:0014066Regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0032252Secretory granule localizationIEAbiological_process
GO:0032862Activation of Rho GTPase activityIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042629Mast cell granuleIEAcellular_component
GO:0043303Mast cell degranulationIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0047496Vesicle transport along microtubuleIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99113710730.01069117430.99999024730.2048052402

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4615529768
GSE13712_SHEARDown-0.1219136648
GSE13712_STATICDown-0.1140502417
GSE19018Down-1.3318656596
GSE19899_A1Down-0.2508557418
GSE19899_A2Down-0.3878634435
PubMed_21979375_A1Down-0.0248639939
PubMed_21979375_A2Down-0.3324631940
GSE35957Down-1.3337950335
GSE36640Down-0.9033009325
GSE54402Down-0.1563180158
GSE9593Up0.1171459412
GSE43922Up0.0116557312
GSE24585Down-0.5248874812
GSE37065Down-0.0136615578
GSE28863_A1Down-0.3991761886
GSE28863_A2Up0.0925049947
GSE28863_A3Up0.1648950964
GSE28863_A4Down-0.0613514656
GSE48662Down-0.0604579358

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT000019qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20483747
hsa-miR-21-5pMIMAT0000076MIRT000019MicroarrayFunctional MTI (Weak)18591254
hsa-miR-335-5pMIMAT0000765MIRT018006MicroarrayFunctional MTI (Weak)18185580
hsa-miR-125b-5pMIMAT0000423MIRT045953CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24213576Increased p-ERK activity results from the dampened HRAS-induced negative feedback response mediated in part through transcriptional upregulation of RAS guanyl-releasing protein 1 (RASGRP1) by PPARbeta/delta
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