HCSGD entry for KIF20A
1. General information
| Official gene symbol | KIF20A |
|---|---|
| Entrez ID | 10112 |
| Gene full name | kinesin family member 20A |
| Other gene symbols | MKLP2 RAB6KIFL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000910 | Cytokinesis | IDA IEA | biological_process |
| GO:0001578 | Microtubule bundle formation | IDA | biological_process |
| GO:0003777 | Microtubule motor activity | IEA | molecular_function |
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005871 | Kinesin complex | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA | biological_process |
| GO:0008017 | Microtubule binding | IEA | molecular_function |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016192 | Vesicle-mediated transport | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9321171156 | 0.0000049010 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.1872242377 |
| GSE13712_SHEAR | Down | -0.7287679201 |
| GSE13712_STATIC | Down | -0.9339266992 |
| GSE19018 | Up | 0.4884098307 |
| GSE19899_A1 | Down | -2.7109716102 |
| GSE19899_A2 | Down | -5.4915611069 |
| PubMed_21979375_A1 | Down | -5.6286218288 |
| PubMed_21979375_A2 | Down | -7.4121682248 |
| GSE35957 | Down | -5.2234045140 |
| GSE36640 | Down | -6.4183302433 |
| GSE54402 | Down | -2.3569776008 |
| GSE9593 | Down | -2.1849313794 |
| GSE43922 | Down | -4.0173181673 |
| GSE24585 | Up | 0.1178439956 |
| GSE37065 | Down | -1.6686852616 |
| GSE28863_A1 | Down | -0.4499554014 |
| GSE28863_A2 | Up | 1.3980422838 |
| GSE28863_A3 | Down | -0.6592541922 |
| GSE28863_A4 | Up | 0.0009588614 |
| GSE48662 | Down | -1.9683395015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023002 | Proteomics | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024718 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026859 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050411 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25961928 | Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance |
| 25961928 | We also demonstrate that FOXM1 regulates the expression of the microtubulin-associated kinesin KIF20A at the transcriptional level directly through a Forkhead response element (FHRE) in its promoter |
| 25961928 | Similar to FOXM1, KIF20A expression is downregulated by paclitaxel in the sensitive MCF-7 breast cancer cells and deregulated in the paclitaxel-resistant MCF-7Tax(R) cells |
| 25961928 | KIF20A depletion also renders MCF-7 and MCF-7Tax(R) cells more sensitive to paclitaxel-induced cellular senescence |
| 25961928 | Crucially, resembling paclitaxel treatment, silencing of FOXM1 and KIF20A similarly promotes abnormal mitotic spindle morphology and chromosome alignment, which have been shown to induce mitotic catastrophe-dependent senescence |
| 25961928 | The physiological relevance of the regulation of KIF20A by FOXM1 is further highlighted by the strong and significant correlations between FOXM1 and KIF20A expression in breast cancer patient samples |
| 25961928 | Statistical analysis reveals that both FOXM1 and KIF20A protein and mRNA expression significantly associates with poor survival, consistent with a role of FOXM1 and KIF20A in paclitaxel action and resistance |
| 25961928 | Collectively, our findings suggest that paclitaxel targets the FOXM1-KIF20A axis to drive abnormal mitotic spindle formation and mitotic catastrophe and that deregulated FOXM1 and KIF20A expression may confer paclitaxel resistance |
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