HCSGD entry for RAD50
1. General information
| Official gene symbol | RAD50 |
|---|---|
| Entrez ID | 10111 |
| Gene full name | RAD50 homolog (S. cerevisiae) |
| Other gene symbols | NBSLD RAD502 hRad50 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000014 | Single-stranded DNA endodeoxyribonuclease activity | IDA | molecular_function |
| GO:0000019 | Regulation of mitotic recombination | IDA | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | TAS | biological_process |
| GO:0000737 | DNA catabolic process, endonucleolytic | IDA | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IMP | molecular_function |
| GO:0004518 | Nuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IMP | biological_process |
| GO:0006281 | DNA repair | IDA IEA TAS | biological_process |
| GO:0006302 | Double-strand break repair | IMP TAS | biological_process |
| GO:0006308 | DNA catabolic process | IDA | biological_process |
| GO:0006310 | DNA recombination | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007004 | Telomere maintenance via telomerase | IDA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |
| GO:0030674 | Protein binding, bridging | IDA | molecular_function |
| GO:0030870 | Mre11 complex | IDA IEA | cellular_component |
| GO:0031954 | Positive regulation of protein autophosphorylation | IDA | biological_process |
| GO:0032508 | DNA duplex unwinding | IMP | biological_process |
| GO:0033674 | Positive regulation of kinase activity | IDA | biological_process |
| GO:0035861 | Site of double-strand break | IDA | cellular_component |
| GO:0045120 | Pronucleus | IEA | cellular_component |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5877094753 | 0.6565803617 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1044333652 |
| GSE13712_SHEAR | Up | 0.0227352729 |
| GSE13712_STATIC | Up | 0.4100367993 |
| GSE19018 | Down | -0.0191742096 |
| GSE19899_A1 | Down | -0.0106184203 |
| GSE19899_A2 | Up | 0.1712442542 |
| PubMed_21979375_A1 | Up | 0.3988513682 |
| PubMed_21979375_A2 | Up | 0.3986787924 |
| GSE35957 | Down | -0.3046678283 |
| GSE36640 | Up | 0.0674285555 |
| GSE54402 | Down | -0.1509386836 |
| GSE9593 | Up | 0.2213079369 |
| GSE43922 | Down | -0.0282726866 |
| GSE24585 | Down | -0.2424902527 |
| GSE37065 | Down | -0.0665675711 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0933340201 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18801192 | RESULTS: We confirm the validity of this screen and show that ING1 interacts specifically with three of the three proteins tested; p38MAPK, MEKK4 and RAD50 |
| 12748277 | Strikingly, inactivation of the Rad50/Rad59 pathway (which is normally required for type II recombination) in cdc13-1 yku70delta or yku70delta tlc1delta mutants, but also in cdc13-1 YKU70(+) tlc1delta mutants, still permitted type II recombination, but this process was now entirely dependent on the Rad51 pathway |
| 12748277 | They also suggest that Rad51 is more efficient than Rad50 in amplifying the sequences left uncovered by the absence of Cdc13 or Yku70 |
| 9366550 | Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae |
| 9366550 | BACKGROUND: Vegetatively dividing cells of Saccharomyces cerevisiae carrying a mutation in RAD50 grow significantly more slowly in rich medium and are sensitive to DNA damage inflicted by X-ray or chemical mutagens |
| 9366550 | RAD50 function is essential for the formation and repair of meiosis-specific double-strand breaks and chromosome stability |
| 9366550 | Comparison of TG1-3 telomeric sequences in an isogenic pair of RAD50 and rad50delta haploid strains showed that they were considerably shortened in the latter |
| 9366550 | Telomeres were restored to the wild-type size in hemizygous RAD50/rad50delta and rad50S/rad50delta strains; however, they showed a significant increase in rad50S/rad50S diploid with a concomitant rise in cell viability |
| 9366550 | Telomeres were stabilized in hemizygous RAD50/rad50delta and rad50S/rad50delta diploids during prolonged growth, suggesting that even a half-dosage of RAD50 is sufficient to conserve the telomere size during successive cell divisions |
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