HCSGD entry for ARPC2
1. General information
| Official gene symbol | ARPC2 |
|---|---|
| Entrez ID | 10109 |
| Gene full name | actin related protein 2/3 complex, subunit 2, 34kDa |
| Other gene symbols | ARC34 PNAS-139 p34-Arc |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005885 | Arp2/3 protein complex | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0019894 | Kinesin binding | IEA | molecular_function |
| GO:0030833 | Regulation of actin filament polymerization | IEA | biological_process |
| GO:0030838 | Positive regulation of actin filament polymerization | IEA | biological_process |
| GO:0031252 | Cell leading edge | IEA | cellular_component |
| GO:0035650 | AP-1 adaptor complex binding | IEA | molecular_function |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0071933 | Arp2/3 complex binding | IEA | molecular_function |
| GO:1900026 | Positive regulation of substrate adhesion-dependent cell spreading | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9049218267 | 0.4406283994 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0723469859 |
| GSE13712_SHEAR | Down | -0.0035079117 |
| GSE13712_STATIC | Down | -0.0004430342 |
| GSE19018 | Up | 0.1755792297 |
| GSE19899_A1 | Up | 0.1014876468 |
| GSE19899_A2 | Up | 0.0620652842 |
| PubMed_21979375_A1 | Down | -0.0022473140 |
| PubMed_21979375_A2 | Down | -0.0691456633 |
| GSE35957 | Down | -0.0582356900 |
| GSE36640 | Down | -0.0082625327 |
| GSE54402 | Up | 0.1183971423 |
| GSE9593 | Up | 0.1042178967 |
| GSE43922 | Up | 0.0717490125 |
| GSE24585 | Up | 0.0301124998 |
| GSE37065 | Down | -0.0066351794 |
| GSE28863_A1 | Down | -0.3018740614 |
| GSE28863_A2 | Down | -0.0693192320 |
| GSE28863_A3 | Down | -0.4061137449 |
| GSE28863_A4 | Down | -0.2082085929 |
| GSE48662 | Down | -0.3240482208 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide | DB08235 | - |
| (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one | DB08236 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-149-5p | MIMAT0000450 | MIRT045659 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048830 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049237 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050988 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
