HCSGD entry for PPIF

1. General information

Official gene symbolPPIF
Entrez ID10105
Gene full namepeptidylprolyl isomerase F
Other gene symbolsCYP3 CyP-M Cyp-D CypD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002931Response to ischemiaISSbiological_process
GO:0003755Peptidyl-prolyl cis-trans isomerase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005753Mitochondrial proton-transporting ATP synthase complexISScellular_component
GO:0005759Mitochondrial matrixIEAcellular_component
GO:0006457Protein foldingIEAbiological_process
GO:0008637Apoptotic mitochondrial changesIEAbiological_process
GO:0010849Regulation of proton-transporting ATPase activity, rotational mechanismISSbiological_process
GO:0010940Positive regulation of necrotic cell deathIMPbiological_process
GO:0016018Cyclosporin A bindingIEAmolecular_function
GO:0016020MembraneTAScellular_component
GO:0032780Negative regulation of ATPase activityISSbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0046902Regulation of mitochondrial membrane permeabilityISSbiological_process
GO:0070301Cellular response to hydrogen peroxideIMPbiological_process
GO:0071243Cellular response to arsenic-containing substanceISSbiological_process
GO:0071277Cellular response to calcium ionISSbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaISSbiological_process
GO:0090201Negative regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:0090324Negative regulation of oxidative phosphorylationISSbiological_process
GO:2000276Negative regulation of oxidative phosphorylation uncoupler activityISSbiological_process
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00272763190.54014631660.14049706461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.4631157771
GSE13712_SHEARUp0.6949777485
GSE13712_STATICUp0.6632173071
GSE19018Down-0.5266734943
GSE19899_A1Up0.5068821927
GSE19899_A2Up1.5365876672
PubMed_21979375_A1Up2.2236375703
PubMed_21979375_A2Up0.1491769504
GSE35957Down-0.2292086423
GSE36640Down-0.9670621163
GSE54402Up1.0413585515
GSE9593Down-0.1397061981
GSE43922Up0.8473555656
GSE24585Down-0.7386919152
GSE37065Up0.2051259570
GSE28863_A1Up0.1480436929
GSE28863_A2Up0.7458343921
GSE28863_A3Down-0.0574940150
GSE28863_A4Up0.1443195493
GSE48662Down-0.5551805563

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CyclosporineDB00091 BTD00003 | BIOD00003
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-EthaneDB02078 EXPT02565
7-AMINO-4-METHYL-CHROMEN-2-ONEDB08168 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001429pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-21-5pMIMAT0000076MIRT005331Luciferase reporter assay//qRT-PCRFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT005331MicroarrayFunctional MTI (Weak)18591254
hsa-miR-124-3pMIMAT0000422MIRT022323Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-7-5pMIMAT0000252MIRT025721SequencingFunctional MTI (Weak)20371350
hsa-miR-7-5pMIMAT0000252MIRT025721MicroarrayFunctional MTI (Weak)19073608
hsa-miR-615-3pMIMAT0003283MIRT040187CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044495CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.