HCSGD entry for ADAM8

1. General information

Official gene symbolADAM8
Entrez ID101
Gene full nameADAM metallopeptidase domain 8
Other gene symbolsCD156 MS2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisISSbiological_process
GO:0001525AngiogenesisISSbiological_process
GO:0002102PodosomeIDAcellular_component
GO:0002523Leukocyte migration involved in inflammatory responseISSbiological_process
GO:0002675Positive regulation of acute inflammatory responseISSbiological_process
GO:0004222Metalloendopeptidase activityIEAmolecular_function
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006954Inflammatory responseIDAbiological_process
GO:0008237Metallopeptidase activityIDAmolecular_function
GO:0008270Zinc ion bindingIEA TASmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0010954Positive regulation of protein processingNASbiological_process
GO:0016337Cell-cell adhesionIEAbiological_process
GO:0022407Regulation of cell-cell adhesionIDAbiological_process
GO:0032010PhagolysosomeIDAcellular_component
GO:0032127Dense core granule membraneIDAcellular_component
GO:0033089Positive regulation of T cell differentiation in thymusISSbiological_process
GO:0035419Activation of MAPK activity involved in innate immune responseISSbiological_process
GO:0042581Specific granuleIDAcellular_component
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0043621Protein self-associationTASmolecular_function
GO:0045780Positive regulation of bone resorptionISSbiological_process
GO:0045785Positive regulation of cell adhesionISSbiological_process
GO:0048247Lymphocyte chemotaxisISSbiological_process
GO:0050714Positive regulation of protein secretionICbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0051044Positive regulation of membrane protein ectodomain proteolysisIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityISSbiological_process
GO:0051897Positive regulation of protein kinase B signalingISSbiological_process
GO:0070245Positive regulation of thymocyte apoptotic processISSbiological_process
GO:0070820Tertiary granuleIDAcellular_component
GO:0071065Alpha9-beta1 integrin-vascular cell adhesion molecule-1 complexIDAcellular_component
GO:0071133Alpha9-beta1 integrin-ADAM8 complexISScellular_component
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:2000309Positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionISSbiological_process
GO:2000391Positive regulation of neutrophil extravasationIDAbiological_process
GO:2000415Positive regulation of fibronectin-dependent thymocyte migrationISSbiological_process
GO:2000418Positive regulation of eosinophil migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49229169480.83616899430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0420686855
GSE13712_SHEARUp0.0707310992
GSE13712_STATICUp0.2283071730
GSE19018Up0.1633781882
GSE19899_A1Up0.1022211457
GSE19899_A2Down-0.0172779017
PubMed_21979375_A1Down-0.0684481418
PubMed_21979375_A2Up0.0259971060
GSE35957Up0.0031790355
GSE36640Down-0.0863718777
GSE54402Up0.2353311039
GSE9593Down-0.0471729675
GSE43922Up0.0109303200
GSE24585Down-0.0410651704
GSE37065Down-0.0547817381
GSE28863_A1Down-0.1355297428
GSE28863_A2Up0.0037951745
GSE28863_A3Up0.3730724502
GSE28863_A4Up0.0899430310
GSE48662Up0.0562951381

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019009MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.