HCSGD entry for ACTR3

1. General information

Official gene symbolACTR3
Entrez ID10096
Gene full nameARP3 actin-related protein 3 homolog (yeast)
Other gene symbolsARP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0002102PodosomeIEAcellular_component
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005885Arp2/3 protein complexTAScellular_component
GO:0006928Cellular component movementTASbiological_process
GO:0007163Establishment or maintenance of cell polarityIEAbiological_process
GO:0008356Asymmetric cell divisionIEAbiological_process
GO:0009743Response to carbohydrateIEAbiological_process
GO:0010592Positive regulation of lamellipodium assemblyIEAbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0030027LamellipodiumIEAcellular_component
GO:0030056HemidesmosomeIEAcellular_component
GO:0030838Positive regulation of actin filament polymerizationIEAbiological_process
GO:0033206Meiotic cytokinesisIEAbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043519Regulation of myosin II filament organizationIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0046677Response to antibioticIEAbiological_process
GO:0050775Positive regulation of dendrite morphogenesisIEAbiological_process
GO:0051491Positive regulation of filopodium assemblyIEAbiological_process
GO:0051653Spindle localizationIEAbiological_process
GO:0060076Excitatory synapseIEAcellular_component
GO:0060271Cilium morphogenesisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95900986660.06297457920.99999024730.4736866515

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4556265601
GSE13712_SHEARDown-0.2631080019
GSE13712_STATICDown-0.1043719929
GSE19018Down-0.5913258186
GSE19899_A1Down-0.0160835807
GSE19899_A2Down-0.1445522177
PubMed_21979375_A1Down-0.2412656794
PubMed_21979375_A2Up0.1527236406
GSE35957Up0.5258585422
GSE36640Up0.2364802402
GSE54402Up0.0125739634
GSE9593Down-0.0371631360
GSE43922Up0.0141885994
GSE24585Down-0.1176897709
GSE37065Down-0.0341618357
GSE28863_A1Down-0.1192271287
GSE28863_A2Up0.0360701365
GSE28863_A3Down-0.1899504527
GSE28863_A4Down-0.2780615235
GSE48662Down-0.9268762202

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamideDB08235 -
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-oneDB08236 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022726Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22370639The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1)
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