HCSGD entry for SNUPN
1. General information
| Official gene symbol | SNUPN |
|---|---|
| Entrez ID | 10073 |
| Gene full name | snurportin 1 |
| Other gene symbols | KPNBL RNUT1 Snurportin1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000339 | RNA cap binding | TAS | molecular_function |
| GO:0000387 | Spliceosomal snRNP assembly | TAS | biological_process |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0034660 | NcRNA metabolic process | TAS | biological_process |
| GO:0061015 | SnRNA import into nucleus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9737077505 | 0.0472500057 | 0.9999902473 | 0.4079859718 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0135729175 |
| GSE13712_SHEAR | Down | -0.5052025309 |
| GSE13712_STATIC | Down | -0.4322701152 |
| GSE19018 | Down | -0.1867971260 |
| GSE19899_A1 | Down | -0.5877358874 |
| GSE19899_A2 | Down | -0.3161542635 |
| PubMed_21979375_A1 | Down | -0.7058054057 |
| PubMed_21979375_A2 | Down | -0.1630360702 |
| GSE35957 | Down | -0.2276319531 |
| GSE36640 | Down | -0.3055268834 |
| GSE54402 | Down | -0.1530756011 |
| GSE9593 | Up | 0.2593363993 |
| GSE43922 | Down | -0.2870474949 |
| GSE24585 | Down | -0.1859859667 |
| GSE37065 | Down | -0.0682354849 |
| GSE28863_A1 | Up | 0.0903702554 |
| GSE28863_A2 | Up | 0.1373937508 |
| GSE28863_A3 | Down | -0.2654933633 |
| GSE28863_A4 | Up | 0.1246136152 |
| GSE48662 | Up | 0.1897028293 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7c-5p | MIMAT0000064 | MIRT051834 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24326307 | HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1 |
| 24326307 | In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation |
| 24326307 | HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence |
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