HCSGD entry for DNAJB6
1. General information
| Official gene symbol | DNAJB6 |
|---|---|
| Entrez ID | 10049 |
| Gene full name | DnaJ (Hsp40) homolog, subfamily B, member 6 |
| Other gene symbols | DJ4 DnaJ HHDJ1 HSJ-2 HSJ2 LGMD1E MRJ MSJ-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001671 | ATPase activator activity | IDA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006457 | Protein folding | IDA | biological_process |
| GO:0030018 | Z disc | IDA | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0031072 | Heat shock protein binding | IDA | molecular_function |
| GO:0032781 | Positive regulation of ATPase activity | IDA | biological_process |
| GO:0034504 | Protein localization to nucleus | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0045109 | Intermediate filament organization | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051087 | Chaperone binding | IDA | molecular_function |
| GO:0060710 | Chorio-allantoic fusion | IEA | biological_process |
| GO:0060715 | Syncytiotrophoblast cell differentiation involved in labyrinthine layer development | IEA | biological_process |
| GO:0060717 | Chorion development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1579382090 | 0.5749355192 | 0.7883731462 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4946221690 |
| GSE13712_SHEAR | Down | -0.1160841047 |
| GSE13712_STATIC | Up | 0.0232943249 |
| GSE19018 | Up | 0.7329507503 |
| GSE19899_A1 | Down | -0.3558703060 |
| GSE19899_A2 | Up | 0.5887518110 |
| PubMed_21979375_A1 | Up | 0.2596783016 |
| PubMed_21979375_A2 | Up | 0.3656662610 |
| GSE35957 | Down | -0.1241073600 |
| GSE36640 | Up | 0.3027955017 |
| GSE54402 | Down | -0.1743566901 |
| GSE9593 | Up | 0.0493569814 |
| GSE43922 | Up | 0.1324182641 |
| GSE24585 | Up | 0.1176296689 |
| GSE37065 | Up | 0.2893130193 |
| GSE28863_A1 | Down | -0.1370838367 |
| GSE28863_A2 | Up | 0.0317570784 |
| GSE28863_A3 | Up | 0.1135355030 |
| GSE28863_A4 | Down | -0.0092550055 |
| GSE48662 | Down | -0.2225880660 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020424 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025240 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20094032 | Misfolded proteins deposited at the cell poles lead to selective re-localization of the DnaK/DnaJ/ClpB disaggregating chaperones, but not of GroEL and Lon to these sites |
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