HCSGD entry for MED16
1. General information
| Official gene symbol | MED16 |
|---|---|
| Entrez ID | 10025 |
| Gene full name | mediator complex subunit 16 |
| Other gene symbols | DRIP92 THRAP5 TRAP95 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003712 | Transcription cofactor activity | IDA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | NAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010469 | Regulation of receptor activity | IDA | biological_process |
| GO:0016592 | Mediator complex | IDA IEA | cellular_component |
| GO:0030375 | Thyroid hormone receptor coactivator activity | IDA | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | NAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
| GO:2000273 | Positive regulation of receptor activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6502862125 | 0.3360879032 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1045593579 |
| GSE13712_SHEAR | Down | -0.0201535835 |
| GSE13712_STATIC | Up | 0.0640229647 |
| GSE19018 | Up | 0.1185302750 |
| GSE19899_A1 | Down | -0.3298962340 |
| GSE19899_A2 | Up | 0.0868427810 |
| PubMed_21979375_A1 | Up | 0.3415496081 |
| PubMed_21979375_A2 | Up | 0.6769261962 |
| GSE35957 | Down | -0.3596766867 |
| GSE36640 | Down | -0.1363378916 |
| GSE54402 | Down | -0.0065678651 |
| GSE9593 | Down | -0.3133761133 |
| GSE43922 | Up | 0.0498900627 |
| GSE24585 | Down | -0.0863022478 |
| GSE37065 | Down | -0.2174279881 |
| GSE28863_A1 | Up | 0.1754397540 |
| GSE28863_A2 | Down | -0.0932485186 |
| GSE28863_A3 | Down | -0.0715255370 |
| GSE28863_A4 | Down | -0.1540584915 |
| GSE48662 | Up | 0.4056721272 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004184 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-346 | MIMAT0000773 | MIRT004240 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030487 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049666 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
