HCSGD entry for HCN4

1. General information

Official gene symbolHCN4
Entrez ID10021
Gene full namehyperpolarization activated cyclic nucleotide-gated potassium channel 4
Other gene symbolsSSS2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002027Regulation of heart rateIMPbiological_process
GO:0005222Intracellular cAMP activated cation channel activityIDAmolecular_function
GO:0005249Voltage-gated potassium channel activityIBA IDAmolecular_function
GO:0005261Cation channel activityTASmolecular_function
GO:0005272Sodium channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIBAcellular_component
GO:0006812Cation transportTASbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008015Blood circulationNASbiological_process
GO:0030552CAMP bindingIEAmolecular_function
GO:0031226Intrinsic component of plasma membraneIDAcellular_component
GO:0042391Regulation of membrane potentialIBAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043195Terminal boutonIEAcellular_component
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0071805Potassium ion transmembrane transportIBA IDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.50612007140.89182029180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1155351188
GSE13712_SHEARDown-0.0198066880
GSE13712_STATICUp0.0036813622
GSE19018Up0.0912240381
GSE19899_A1Up0.0390514423
GSE19899_A2Up0.1639748505
PubMed_21979375_A1Down-0.0002370979
PubMed_21979375_A2Down-0.0432936213
GSE35957Up0.2854728850
GSE36640Up0.0426368561
GSE54402Up0.0162479868
GSE9593Down-0.0753906247
GSE43922Up0.1607389169
GSE24585Down-0.1117401383
GSE37065Down-0.0272432647
GSE28863_A1Down-0.1925446932
GSE28863_A2Down-0.1867009851
GSE28863_A3Up0.2336757525
GSE28863_A4Up0.2646944534
GSE48662Up0.0218522262

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT000329Luciferase reporter assayFunctional MTI18458081
hsa-miR-1MIMAT0000416MIRT000933qRT-PCR//Luciferase reporter assay//Western blot//Reporter assayFunctional MTI18458081
hsa-miR-1MIMAT0000416MIRT000933MicroarrayFunctional MTI (Weak)18668037
hsa-miR-133bMIMAT0000770MIRT016694Reporter assay;Western blot;qRT-PCR;OtherFunctional MTI18458081
hsa-miR-192-5pMIMAT0000222MIRT026129MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT00004161hsa-miR-1{Western blot}{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}{overexpression by mature miRNA transfection}18458081
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.