HCSGD entry for SH2B3
1. General information
| Official gene symbol | SH2B3 |
|---|---|
| Entrez ID | 10019 |
| Gene full name | SH2B adaptor protein 3 |
| Other gene symbols | IDDM20 LNK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0035162 | Embryonic hemopoiesis | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042301 | Phosphate ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0011753505 | 0.6488757114 | 0.0918976261 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.0566358462 |
| GSE13712_SHEAR | Up | 0.0240677038 |
| GSE13712_STATIC | Up | 0.0694506593 |
| GSE19018 | Down | -1.6963073694 |
| GSE19899_A1 | Up | 2.0346551176 |
| GSE19899_A2 | Up | 1.6042069188 |
| PubMed_21979375_A1 | Up | 3.4424589005 |
| PubMed_21979375_A2 | Up | 1.7997386019 |
| GSE35957 | Down | -0.8601246671 |
| GSE36640 | Up | 0.0088666783 |
| GSE54402 | Up | 3.0182105283 |
| GSE9593 | Up | 0.4427106364 |
| GSE43922 | Up | 1.2044153297 |
| GSE24585 | Up | 0.1608665207 |
| GSE37065 | Up | 0.0402134517 |
| GSE28863_A1 | Down | -0.1352604995 |
| GSE28863_A2 | Up | 0.1595193412 |
| GSE28863_A3 | Up | 0.0829192380 |
| GSE28863_A4 | Up | 0.0940511894 |
| GSE48662 | Down | -0.2951533370 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pazopanib | DB06589 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018890 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023128 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023453 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024840 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026822 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030230 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037031 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26677855 | The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease) |
| 22812478 | Lnk deficiency partially mitigates hematopoietic stem cell aging |
| 22812478 | The adaptor protein Lnk is an important negative regulator of HSC homeostasis, as Lnk deficiency is associated with a 10-fold increase in HSC numbers in young mice |
| 22812478 | Importantly, HSCs from aged Lnk null mice possess greatly enhanced self-renewal capacity and diminished exhaustion, as evidenced by serial transplant experiments |
| 22812478 | In addition, Lnk deficiency ameliorates the aging-associated lineage bias |
| 22812478 | Taken together, these results suggest that loss of Lnk partially mitigates age-related HSC alterations |
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