HCSGD entry for BCL2L11
1. General information
| Official gene symbol | BCL2L11 |
|---|---|
| Entrez ID | 10018 |
| Gene full name | BCL2-like 11 (apoptosis facilitator) |
| Other gene symbols | BAM BIM BOD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001782 | B cell homeostasis | IEA | biological_process |
| GO:0001783 | B cell apoptotic process | IEA | biological_process |
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0002262 | Myeloid cell homeostasis | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008017 | Microtubule binding | IDA IEA | molecular_function |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IDA | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0019898 | Extrinsic component of membrane | IEA | cellular_component |
| GO:0030879 | Mammary gland development | IEA | biological_process |
| GO:0032464 | Positive regulation of protein homooligomerization | IDA | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA IEA | biological_process |
| GO:0035148 | Tube formation | IEA | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0043029 | T cell homeostasis | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IMP TAS | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043583 | Ear development | IEA | biological_process |
| GO:0045787 | Positive regulation of cell cycle | IEA | biological_process |
| GO:0046620 | Regulation of organ growth | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048066 | Developmental pigmentation | IEA | biological_process |
| GO:0048070 | Regulation of developmental pigmentation | IEA | biological_process |
| GO:0048536 | Spleen development | IEA | biological_process |
| GO:0048538 | Thymus development | IEA | biological_process |
| GO:0048563 | Post-embryonic organ morphogenesis | IEA | biological_process |
| GO:0060139 | Positive regulation of apoptotic process by virus | IEA | biological_process |
| GO:0060154 | Cellular process regulating host cell cycle in response to virus | IEA | biological_process |
| GO:0070242 | Thymocyte apoptotic process | IEA | biological_process |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IGI IMP | biological_process |
| GO:0097140 | BIM-BCL-xl complex | IDA | cellular_component |
| GO:0097141 | BIM-BCL-2 complex | IDA | cellular_component |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IEA | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1900740 | Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | biological_process |
| GO:1902110 | Positive regulation of mitochondrial membrane permeability involved in apoptotic process | IEA | biological_process |
| GO:1902263 | Apoptotic process involved in embryonic digit morphogenesis | IEA | biological_process |
| GO:2000271 | Positive regulation of fibroblast apoptotic process | IDA | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IMP TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4576686106 | 0.2286934539 | 0.9999902473 | 0.9206014375 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0538983789 |
| GSE13712_SHEAR | Down | -0.3594156863 |
| GSE13712_STATIC | Down | -0.6425203159 |
| GSE19018 | Up | 0.0014371706 |
| GSE19899_A1 | Up | 0.0288559270 |
| GSE19899_A2 | Down | -0.0383548067 |
| PubMed_21979375_A1 | Down | -0.1146929614 |
| PubMed_21979375_A2 | Down | -0.0898257843 |
| GSE35957 | Down | -0.1876468810 |
| GSE36640 | Down | -0.4912928886 |
| GSE54402 | Down | -0.2339477686 |
| GSE9593 | Down | -0.4912230479 |
| GSE43922 | Up | 0.0137500677 |
| GSE24585 | Up | 0.4297068662 |
| GSE37065 | Up | 0.3263720146 |
| GSE28863_A1 | Up | 0.4888838383 |
| GSE28863_A2 | Up | 0.4022004958 |
| GSE28863_A3 | Up | 0.1103018741 |
| GSE28863_A4 | Up | 0.0075867197 |
| GSE48662 | Up | 0.1121100015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT000140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT006366 | Luciferase reporter assay//Western blot | Functional MTI | 21471404 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT000785 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT001206 | Luciferase reporter assay//Western blot | Functional MTI | 19136465 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT001206 | qRT-PCR//Western blot//Northern blot//Luciferase reporter assay | Functional MTI | 18493594 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT001206 | Luciferase reporter assay//Western blot | Functional MTI | 20227518 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT003413 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18328430 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT003413 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 19422085 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT003739 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18676839 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT003739 | qRT-PCR//Western blot | Functional MTI | 21816906 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT004452 | Luciferase reporter assay | Functional MTI | 18728182 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT004523 | Luciferase reporter assay | Functional MTI | 18728182 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT005767 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20841506 |
| hsa-miR-494-3p | MIMAT0002816 | MIRT006981 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23012423 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019539 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT019675 | Microarray//qRT-PCR;Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030547 | Western blot | Functional MTI | 18308931 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052551 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-19a-3p | MIMAT0000073 | NA | hsa-miR-19a | {Western blot} | {overexpression by miRNA precursor transfection} | 20299512 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | 19438724 | |||
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | 19438724 | |||
| hsa-miR-25-3p | MIMAT0000081 | NA | hsa-miR-25 | {Western blot} | {overexpression by miRNA mimics tranfection} | 19422085 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21784712 | Important findings included significant upregulation of p53 and several proapoptotic genes (including apoptosis-inducing factor, mitochondrion-associated 1, BCL2-like 11 [an apoptosis facilitator]; caspase 7 apoptosis-related cysteine peptidase; proteasome 26S subunit nonadenosine triphosphatase 10, programmed cell death 6, and reticulon 3) |
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