HCSGD entry for LOC100128922


1. General information

Official gene symbolLOC100128922
Entrez ID100128922
Gene full nameconnexin
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

Not in the Gene ontology

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77270379160.57594689790.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0281869699
GSE13712_SHEARDown-0.2350276735
GSE13712_STATICUp0.2059488989
GSE19018Up0.0109059811
GSE19899_A1Down-0.0029168322
GSE19899_A2Up0.0291400498
PubMed_21979375_A1Down-0.0223162930
PubMed_21979375_A2Down-0.0836343115
GSE35957Down-0.0085118869
GSE36640Down-0.0050354029
GSE54402Up0.0618704810
GSE9593Down-0.0430365186
GSE43922Up0.0210062616
GSE24585Up0.0442702720
GSE37065Up0.0489805078
GSE28863_A1Up0.2762177073
GSE28863_A2Up0.2125745929
GSE28863_A3Down-0.3990351420
GSE28863_A4Down-0.0681989456
GSE48662Down-0.0974841505

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22611193Connexin-43 (Cx43), a connexin constituent of gap junctions (GJs) is expressed in HSCs, down-regulated during differentiation, and postulated to be a self-renewal gene
15040891Dye transfer assay for gap junction function and immunofluorescent staining for connexin 43 protein distribution were done respectively
14516786Measurement of Connexin 43 indicated a decreased expression of the protein, which suggests an impaired gap junction communication in senescent-like HDFs
12213561Drop of connexin 43 in replicative senescence of human fibroblasts HEL-299 as a possible biomarker of senescence
12213561The expression of connexin 43 (cx43) and cell-cell communication were studied in replicative senescence of cultured HEL-299 fibroblasts
8082719Northern and Western analyses reveal that the levels of both cx43 (connexin 43) messenger RNA and protein decline as HUVEC age in vitro
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