HCSGD entry for CDKN2B-AS1

1. General information

Official gene symbolCDKN2B-AS1
Entrez ID100048912
Gene full nameCDKN2B antisense RNA 1
Other gene symbolsANRIL CDKN2B-AS CDKN2BAS NCRNA00089 p15AS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

Not in the Gene ontology

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52622113900.82731589610.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0739680893
GSE13712_SHEARUp0.0860592092
GSE13712_STATICDown-0.0570999992
GSE19018Down-0.0401840990
GSE19899_A1Up0.2648553636
GSE19899_A2Down-0.0777377228
PubMed_21979375_A1Up0.3595734029
PubMed_21979375_A2Down-0.1346975060
GSE35957Up0.2443767560
GSE36640Down-0.1500882674
GSE54402Up0.1857904703
GSE9593Down-0.0818039595
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.1425715273
GSE28863_A2Down-0.1666023937
GSE28863_A3Down-0.2195292979
GSE28863_A4Up0.2144986578
GSE48662Down-0.0679362435

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26708220ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture
26708220However, the role of ANRIL in cancer cell proliferation is less well understood
26708220Here we report that ANRIL is involved in the proliferation of colorectal cancer HCT116 cells in two- and three-dimensional culture
26708220Silencing ANRIL by both transfection with small interfering RNA and retrovirally produced small hairpin RNA reduced HCT116 cell proliferation in both two- and three-dimensional culture
26708220HCT116 cells depleted for ANRIL were arrested in the S phase of cell cycle
26708220Notably, silencing ANRIL did not result in the activation of expression of the INK4 locus
25501747Here, we show that the exogenous and endogenous expression of an oncogenic form of small GTPase Ras (called oncogenic Ras) decrease the expression of lncRNA ANRIL (antisense non-coding RNA in the INK4 locus), which is involved in the regulation of cellular senescence
25501747These findings indicate that oncogenic Ras regulates the expression of a large number of lncRNAs including functional lncRNAs, such as ANRIL and PANDA
20956613ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
20956613While the exact role of ANRIL awaited further elucidation, common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes
20956613Among the cluster, ANRIL expression showed the strongest association with the multiple phenotypes linked to the 9p21
20956613More recent GWAS also identified ANRIL as a risk locus for gliomas and basal cell carcinomas in accordance with the princeps observation
20956613Moreover, a mouse model has confirmed the pivotal role of ANRIL in regulation of CDKN2A/B expression through a cis-acting mechanism and its implication in proliferation and senescence
20956613ANRIL identification emphasizes the underestimated role of long noncoding RNAs
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