HCSGD entry for AKT3
1. General information
| Official gene symbol | AKT3 |
|---|---|
| Entrez ID | 10000 |
| Gene full name | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) |
| Other gene symbols | MPPH PKB-GAMMA PKBG PRKBG RAC-PK-gamma RAC-gamma STK-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000002 | Mitochondrial genome maintenance | IMP | biological_process |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007165 | Signal transduction | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6282588010 | 0.0772363816 | 0.9999902473 | 0.5256871251 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6859394899 |
| GSE13712_SHEAR | Down | -0.4459242812 |
| GSE13712_STATIC | Down | -0.3426488848 |
| GSE19018 | Up | 0.5729293189 |
| GSE19899_A1 | Down | -0.0968844023 |
| GSE19899_A2 | Down | -0.0675935616 |
| PubMed_21979375_A1 | Down | -0.2981903254 |
| PubMed_21979375_A2 | Down | -0.4007628593 |
| GSE35957 | Up | 0.5464724815 |
| GSE36640 | Down | -0.6648638639 |
| GSE54402 | Up | 0.2860699373 |
| GSE9593 | Up | 0.1344629414 |
| GSE43922 | Down | -0.2197514925 |
| GSE24585 | Up | 0.1933992662 |
| GSE37065 | Up | 0.0637405423 |
| GSE28863_A1 | Up | 0.1101504303 |
| GSE28863_A2 | Up | 0.1371167864 |
| GSE28863_A3 | Down | -0.3149679373 |
| GSE28863_A4 | Down | -0.3803597619 |
| GSE48662 | Up | 0.1698393740 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003099 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT003329 | Luciferase reporter assay | Functional MTI | 23233752 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT003334 | Luciferase reporter assay | Functional MTI | 23233752 |
| hsa-miR-519d-3p | MIMAT0002853 | MIRT006197 | Luciferase reporter assay//Western blot | Functional MTI | 22262409 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020391 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022432 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-146b-5p | MIMAT0002809 | MIRT041618 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25323119 | MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3 |
| 25323119 | AKT3 was identified as a direct target of miR-22, and restoration of AKT3 expression attenuated the effects of miR-22 in young EPCs |
| 25323119 | CONCLUSION: Our results indicate that miR-22 induces EPC senescence by downregulating AKT3 expression, providing a potential novel target for the reversal of EPC dysfunction in angiogenesis |
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